1. Mersin University TURKEY
Association between CARD15/NOD2 gene polymorphisms and Ulcerative colitis and Crohn’s disease in Turkish population
Songül BUDAK DILER
Niğde University
TURKEY
Ebru DERICI EKER
Mersin University TURKEY
Fikriye POLAT
Kocaeli University
TURKEY
Serkan YARAS
Mersin University
TURKEY

2. Ulcerative colitis (UC) and Crohn’s disease (CD) are chronic inflammatory bowel diseases (IBD) which are similar to each other for their clinical features and epidemiology.
Although pathogenesis of these diseases has not been well known yet, one of the most viable hypotheses is the genetic predisposition.
Crohn’s disease

3. This study included 153 healthy controls and 107 patients (42 CD and 65 UC) with CD and UC. The P268S and M863V gene regions were amplified using polymerase chain reaction (PCR), detected by restriction fragment length polymorphism (RFLP).
CARD15/NOD2 polymorphism in patients with Crohn’s Disease (CD) and Healthy Controls

4. Conflict of Interests: None
CARD15/NOD2 polymorphism in patients with Ulcerative Colitis (UC) and Healthy Controls
212 bp and 160 bp were found in wild-type M863V in all subjects and no other mutant band of M863V was detected using PCR-RFLP. There are no association P268S and M863V polymorphisms between patients with CD and UC and the control groups in Turkish population.
Conflict of Interests: None