1. Aroma & Flavor Chemistry Department National Research Center
Nanotechnology & its Application in the delivery of Volatile Oils & Flavors
Amr E. Edris
Professor
Aroma & Flavor Chemistry Department
National Research Center
Egypt

2. Used as targeted delivery systems
1- Medicine
~ 20 nm
Used as targeted delivery systems
for cancer treatment
Solution of gold nano-particles

3. Silver
Silver nano-particles
(Anti-microbial activity)
Wound dressing

4. 2- Energy Silicon nano-particles Silver nano-particles
Production of more efficient solar energy absorping cells

5. 3- Nutrition Nanotechnology Enhances Bioavailability (5.0 % av.)
Vitamin C
20.0% av.
Curcumine
1.0% av.
Nano-encapsulated Vit C
(93.0% av.)
Nano-encapsulated curcumine
(5.0 % av.)

6. Can We Apply Nanotechnology in Fragrance & Flavors Industry ?

7. Yes: by formulating Environmental Friendly Fragrance
80 % organic solvent, 20 % volatile oil
Ethanol
Di-propylene glycol
Diethyl phthalate

8. Environmental Protection Agency
(EPA)
calls for reduction of volatile organic compounds emission
Using
Organic Solvents

9. Global Fragrance Market
(in billion U.S. dollars)*
$51.0

10. Q: What shall Fragrance companies do ??
A: Replace organic solvent with water !!
Volatile oil

11. Nanotechnology Can Help (Formulation of water-based nanoemulsions)+
Water
Surfactant
High pressure valve homogenizer
Water based fragrance
(Organic Solvent Free)

12. (Organic Solvent Free)
Water Based Fragrance
(Organic Solvent Free)
NANO
Emulsion
MACRO
Emulsion
Particle size
100 nm nm
Particle size
> 200 nm

13. Thermodynamically non stable
During Storage in the Bottle
NANO
Emulsion
MACRO
Emulsion
Thermodynamically non stable

14. Microemulsion Approach
can solve this problem +
Water
Excess Surfactant
No machine is needed
Water based fragrance

15. Compare Appearance & Stability of these Water Based Fragrance
Thermodynamically
Stable
(p.s nm)
Thermodynamically
non stable
(p.s nm)
Thermodynamically
non stable
(p.s. > 200 nm)

16. HOW ? What is the mechanism
Water-hating group
(Tail)
Water-loving group
(Head)
Surfactant molecule

17. In water: surfactant take certain orientation
“Self- assembly behavior”
Aggregate
(micelle)
“nano-capsule”
2 nm - 10 nm
Increase surfactant concentration

18. Titrate your fragrance oil !! Surfactant aggregates in water
Shake
Surfactant aggregates in water
Water based fragrance
(10 nm)

19. Environmental friendly fragrance (100% water-based)
Demonstration: تجربة عملية للعرض
Nano-encapsulation
Microemulsion
Tuberose
Environmental friendly fragrance (100% water-based)

20. Nanotechnology in Using Volatile Oils in Personal Care Products
Mouth Wash
(against oral bacteria)
20 % Alcohol

21. (Microemulsion Approach)
Now in the Market
حاليا بالاسواق

22. Nanotechnology in Using Volatile Oils in Food Flavoring & Preservation
Hoda S. El-Sayed, Remigius Chizzola, Asmaa A. Ramadan, Amr E. Edris A
Food Chemistry
(2017)
221; B
P.S.= 10.1 nm

23. Nanotechnology in using Volatile Oils as Antibiotics
Hamdy A. Shaaban, Z. Sadek, A.E. Edris, and A. Saad-Hussein
0.2% % % % %
Nigella sativa
حبة البركة
J. Oleo Science
(2015)
64(2);
P.S.= 8.6 nm

24. Amr Edris
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