1. Headache and migraine

2. Worrisome headache
1-most sever on awakening. 2-that awaken the patient in the middle of night. 3-severly exacerbated on coughing or bending. 4-acute without previous history. 5-present daily & getting progressively more sever. 6-associated with vomiting.

3. Cyclic vomiting
1- mainly occur in infant and young children.
2- recurrent vomiting (dehydration with electrolyte disturbance).
3- fever , abdominal pain , diarrhea.
3- pallor, fright follow by deep sleep→ releave symptoms.
4- family history of migraine.
5- typical migraine headache in future.
Treatment:
1- fluid replacement.
2- rectal antiemetic (ondansetron)
D.Dx:(intestinal obstruction, peptic ulcer, IBD ,inborn error of metabolism ,CNS lesion).

4. Seizures in childhood Seizures (convulsion): Epilepsy:
Define as is a transient occurrence of signs and/or symptoms resulting from abnormal excessive neuronal activity in the brain.
Epilepsy:
is a disorder of the brain characterized by an enduring predisposition to generate seizures, it is considered to be present when two or more unprovoked seizures occur at an interval greater than 24 hr apart

7. Generalized tonic clonic, tonic & clonic seizures
Most common childhood type.
May follow a focal seizure (second generalization) or occur de novo. If associated with an aura, suggesting a focal origin of the epileptiform discharge.
Loss of posture& consciousness →tonic stiffening & upward deviation of eyes →pooling of secretion ,pupillary dilation ,diaphoresis ,HT → clonic jerk →briefly tonic again followed by flaccidity &urinary incontinence.
Postictally, children are initially semicomatose and typically remain in a deep sleep from 30 min to 2 hr.
Treatment:
A B C
Medication :diazepam( mg)I.V+phenobarbiton10-20 mg I.V
History & physical exam.

9. Absence seizures 6-8% age 5-8 yr
brief loss of environmental awareness.(NO loss of conscious)
automatism(eye fluttering, head bobbing, lip smacking)
neurological exam. &brain imaging are normal.
Never associated with an aura.
last few seconds.
patient have hundreds of seizures /day
seizure provoke by hyperventilation for 3-5 min.
characteristic EEG patterns: synchronous 3-Hz spike-and-wave activity with frontal accentuation.
Treatment :Ethosuximide. alternatives are valproate or lamotrigine.

10. Infantile spasms(west syndrome)
Begin between the age of 2-12 mo.
Consists of a triad of : infantile spasms( usually occure in clusters especially in drowsiness or upon arousal) , developmental regression, and typical EEG picture called (hypsarrhythmia).
Of 3 types: 1-flexsters spasm 2- extensor spasm 3- mixed .
Mixed spasm is the most common type.
A cry may precede or follow the spasm, (that confuse with colic).
The clusters of seizures may persist for minutes.
Prognosis is poor.
Recognizing of west syndrome, is a medical emergency because if diagnosis delayed ≥ 3 wk. , it can affect the long-term prognosis.

11. Cryptogenic group(40%)good response to therapy without clear etiology.
Symptomatic type (60%)poor response to therapy with clear etiology (e.g. metabolic like PKU ,congenital malformation of the brain , tuberous sclerosis, congenital infection…etc.
treatment
ACTH
Vegabatrine
Valproic acid
Benzodiazepine

12. Febrile seizures Definition :
Genetic predisposition to seizures in infancy that precipitate by rapid rise in body temperature.
*Occur in 2-5% of children .
* age 6 months-7 years (50% occur between 1-2 yrs) with a temperature ≥ 38ċ that is not due to CNS infection or metabolic disturbance, and in the absence of history of prior afebrile seizures..

13. *types:
1- simple febrile convulsion: generalized, last<15 minutes ,occur once in 24 hr , it does not carry a risk of epilepsy or mortality.
2- complex febrile convulsion focal ,>15 ms, >once/24 hr
3- febrile status epilepticus : when febrile convulsion last > 30 min.

14. Prognosis:
Excellent
Normal IQ
Further febrile seizure occur

15. Risk factors for subsequent epilepsy including:
Simple FC :1%
Complex FC: 6%
Focal complex:29%
Neurodevelepmental abnormalities :33%

16. Approach to patient with FC:
*assess the cause of fever by proper history, general exam.& investigations e.g. CBP , blood glucose , serum electrolytes , CSF exam. By LP should be done in any infant <18 mon. with FC because seizure may be the only manifestation of meningitis, especially if patient had received antibiotics which mask the other features of meningitis.
*assess the risk factors of recurrence.
*assess the risk factors for later epilepsy.

17. Treatment:
*in case of febrile status epilepticus, iv benzodiazepines, phenobarbital, phenytoin,or valproate.
*in general , antiepileptic therapy is not recommended for children with simple FC, but if patient has risk factors for recurrences, parents should be educated about how to handle the seizure if recur& last >5 min. by rectal diazepam or buccal/intranasal midazolam.
*management of underlying illness also important part in general RX of FC. Antipyretic can reduce discomfort of child, but not reduce the risk of having recurrent FC.

18. *iron deficiency has been associated with increase the risk of FC, and thus screening &Rx for it.
*prevention: if the parents are very anxious about their child`s seizure, intermittent oral diazepam 0.33mg/kg or rectal suppository 0.5 mg/kg every 8 hr. can be given during febrile illness to prevent recurrence of FC.

19. Laboratory evaluation of seizures
CBC
Blood chemistry: glucose, Ca, Na, Cl,HCO3, Mg, Ph. .
Urea & creatinine.
Blood & urine for toxicology screen.
In neonates blood for ammonia & inborn error of metabolism.
CSF analysis.
EEG & brain imaging.
Viral study specially for enterovirus.

20. Principles of seizure therapy
No need for long term treatment of benign febrile convulsion.
Therapy indicated for absence & atypical absence seizures , infantile spasm.
Single , cheap , less toxic drug is the goal that lead to better compliance.
Duration of therapy:
generalized tonic clonic ,tonic, clonic , absence &partial seizures not> than 2-4 yrs.
Myoclonic seizures , atypical absence treatment for life.

21. Approach to the child with a suspected convulsive disorder

22. Risk for recurrence of seizures after discontinuation of therapy
Those children who are neurologically abnormal.
Those having seizures that were initially difficult to control.
Those having persistent epileptiform EEGs.

23. Status epilepticus
Is defined as continuous seizure activity or recurrent seizure activity without regaining consciousness lasting for > 30 min.
Impending status epilepticus : is referred to seizure that last between 5 to 30 min.
Etiology:
1-febrile status epilepticus.
2-new-onset epilepsy
3-drug withdrawal in patient on antiepileptic.
4-drug intoxication
5-hypoglycemia

24. 6-electrolytes imbalance (hypocalcemia, hyponatremia , hypomagnesemia)
6-electrolytes imbalance (hypocalcemia, hyponatremia , hypomagnesemia). 7- acute head trauma 8-encephalitis & meningitis. 9-postinfectious encephalitis. 10-ischemic stroke 11-intracranial hemorrhage 12- inborne error of metabolism. 13-brain tumor.

25. Investigation :
-Laboratory studies: serum glucose, sodium, calcium , blood and spinal fluid cultures, toxic screen and tests for inborn error of metabolism. Antiepileptic drug levels if patient is already on an antiepileptic.
-EEG: is helpful in identifying the types of status epilepticus.
-neuroimaging: needs to be considered after the child has been stabilized.

26. Treatment :
*Status epilepticus is a medical emergency that better managed in the ICU because it requires initial and continuous attention to securing airway , breathing, and circulation with continuous monitoring of vital sign with attention to the systemic complication because some develop multiorgan failure , as well as management of underlying etiology. .

27. PHARMACOLOGIC MANAGEMENT
Initial treatment:
Benzodiazepine:
  Lorazepam mg/kg
  Diazepam mg/kg
  Midazolam mg/kg
Second line treatment: if the sz not resolved after 2 doses of benzodiazepine.
Fosphenytoin mg/kg (phenytoin equivalents)
Phenobarbital mg/kg
Valproic acid 20 mg/kg
3rd line treatment: continous infusions of
Pentobarbital or midazolam
+ continous EEG monitoring
4th line treatment:
General anesthesia