1. Francisella tularensis
V. Mosley F2013
Modified by DYH
Gram negative
Small, pleomorphic coccobacillus
Encapsulated
non-motile
causes tularemia
also called glandular fever, rabbit fever, tick fever, and deer fly fever
Infects
through the bite of infected insects (ex. ticks and deerflies)
by handling infected sick or dead animals (ex. rabbits, rodents, and hares)
by eating or drinking contaminated food or water
by inhaling airborne bacteria
Table 1 Overall features of the genome of F. tularensis strain SCHU S4
Size
1,892,819 bp
G+C content (%)
32.9
CDS
1,804
Coding percentage
79.4
Unique genes
302
Pseudogenes or gene fragments
201
IS elements 74
  ISFtu1 (IS630 family) 50
  ISFtu2 (IS5 family) 16
  ISFtu3 (ISHpaI-IS1016 family) 3
  ISFtu4 (IS982 family) 1
  ISFtu5 (IS4 family)
rRNAs
3 operons
tRNAs 38
Other stable RNAs 7
Subspecies (Human isolate)
buffered charcoal yeast extract; (B) chocolate agar medium; (C) sheep’s blood agar; (D) cysteine heart agar.

2. Francisella tularensis
V. Mosley F2013
Modified by DYH
Virulence factors not well studied
hemolytic agents
may facilitate degradation of the phagosome
NlyA (hemolysin activity )
ATP binding cassette (ABC) proteins
may be linked to the secretion of virulence factors
type IV pili
bind to the exterior of a host cell
thus become phagocytosed
IglC (23-kD protein )
phagosomal breakout and intracellular replication
Down regulates immune response to increase growth time
AcpA
inhibts the respiratory burst
No natural resistance to antibiotics used to treat the diesease
Tularemia. Number of reported cases - United States and U.S. territories, 2007