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Cortical Changes Associated with Depression and Antidepressant Use in Alzheimer and Lewy Body Dementia: An MRI Surface-based Morphometric Study  Alexander.

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Presentation on theme: "Cortical Changes Associated with Depression and Antidepressant Use in Alzheimer and Lewy Body Dementia: An MRI Surface-based Morphometric Study  Alexander."— Presentation transcript:

1 Cortical Changes Associated with Depression and Antidepressant Use in Alzheimer and Lewy Body Dementia: An MRI Surface-based Morphometric Study  Alexander V. Lebedev, M.D., Mona K. Beyer, M.D., Ph.D., Friederike Fritze, M.D., Eric Westman, Ph.D., Clive Ballard, M.D., Ph.D., Dag Aarsland, M.D., Ph.D.  The American Journal of Geriatric Psychiatry  Volume 22, Issue 1, Pages 4-13.e1 (January 2014) DOI: /j.jagp Copyright © 2014 American Association for Geriatric Psychiatry Terms and Conditions

2 Figure 1 Depression-associated cortical thinning in mild dementia.
Notes: Clusters are colored according to their significance. Depression-associated thinning was observed in left dorsolateral prefrontal, anterior temporal regions, and right medial prefrontal, orbitofrontal, and inferior temporal areas. The American Journal of Geriatric Psychiatry  , 4-13.e1DOI: ( /j.jagp ) Copyright © 2014 American Association for Geriatric Psychiatry Terms and Conditions

3 Figure 2 Treatment-associated cortical thinning in mild dementia.
Notes: Thinning was observed in the right parahippocampal region. The American Journal of Geriatric Psychiatry  , 4-13.e1DOI: ( /j.jagp ) Copyright © 2014 American Association for Geriatric Psychiatry Terms and Conditions

4 Figure A1 The American Journal of Geriatric Psychiatry  , 4-13.e1DOI: ( /j.jagp ) Copyright © 2014 American Association for Geriatric Psychiatry Terms and Conditions

5 Figure A2 The American Journal of Geriatric Psychiatry  , 4-13.e1DOI: ( /j.jagp ) Copyright © 2014 American Association for Geriatric Psychiatry Terms and Conditions


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