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Cell survival curves. A) Cells are exposed either in monolayer or in suspension culture to different doses of a drug for a given time, or to a single dose.

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Presentation on theme: "Cell survival curves. A) Cells are exposed either in monolayer or in suspension culture to different doses of a drug for a given time, or to a single dose."— Presentation transcript:

1 Cell survival curves. A) Cells are exposed either in monolayer or in suspension culture to different doses of a drug for a given time, or to a single dose of the drug for a variable time. The cells are then washed in fresh medium and serial dilutions are plated in Petri dishes; colonies formed from surviving cells are counted, usually 10 to 14 days later. B) Experimentally determined cell survival curve for murine EMT6 cells exposed to the drug mitoxantrone. Note that surviving fraction is plotted using a logarithmic scale against dose on a linear scale. Source: Discovery and Evaluation of Anticancer Drugs, The Basic Science of Oncology, 5e Citation: Tannock IF, Hill RP, Bristow RG, Harrington L. The Basic Science of Oncology, 5e; 2016 Available at: Accessed: December 02, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

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