1. Date of download: 11/14/2017
Copyright © ASME. All rights reserved.
From: Stretching Affects Intracellular Oxygen Levels: Three-Dimensional Multiphysics Studies
J Biomech Eng. 2012;134(6): doi: /
Figure Legend:
The surface geometries of cells A and B (undeformed condition), reconstructed in the Virtual Cell software. Each cell model also contains a nucleus (not shown).

2. Date of download: 11/14/2017
Copyright © ASME. All rights reserved.
From: Stretching Affects Intracellular Oxygen Levels: Three-Dimensional Multiphysics Studies
J Biomech Eng. 2012;134(6): doi: /
Figure Legend:
Finite element simulations of the radial stretching of cell B: Deformed shapes and strain distributions across the plasma membrane (left column) and the nucleus (right column)

3. Date of download: 11/14/2017
Copyright © ASME. All rights reserved.
From: Stretching Affects Intracellular Oxygen Levels: Three-Dimensional Multiphysics Studies
J Biomech Eng. 2012;134(6): doi: /
Figure Legend:
Example oxygen concentration distributions at time t = 0.008 s in the cytosol of cell A, at the undeformed state (top frames) and deformed state, where the substrate is being stretched to 24% strain (bottom frames). The left and right frames per each deformation condition show O2 distributions at the inferior surface of the cell and at an additional, horizontal cross-section around the inferior nuclear surface, respectively.

4. Date of download: 11/14/2017
Copyright © ASME. All rights reserved.
From: Stretching Affects Intracellular Oxygen Levels: Three-Dimensional Multiphysics Studies
J Biomech Eng. 2012;134(6): doi: /
Figure Legend:
Mean oxygen concentration curves within (a) the cytosol (COC(t), Eq. )) and (b) the nucleus (NOC(t), Eq. ) for cell A, for different substrate strain levels at the 0–24% strain range and for a medium temperature of 37 °C

5. Date of download: 11/14/2017
Copyright © ASME. All rights reserved.
From: Stretching Affects Intracellular Oxygen Levels: Three-Dimensional Multiphysics Studies
J Biomech Eng. 2012;134(6): doi: /
Figure Legend:
Mean oxygen concentration curves within (a) the cytosol and (b) the nucleus for cell A, for different substrate strain levels at the 0–24% strain range, when there is no oxygen in the medium and for a medium temperature of 37 °C

6. Date of download: 11/14/2017
Copyright © ASME. All rights reserved.
From: Stretching Affects Intracellular Oxygen Levels: Three-Dimensional Multiphysics Studies
J Biomech Eng. 2012;134(6): doi: /
Figure Legend:
Time coefficients τ of the exponential fits to time courses of intracellular oxygen concentrations in (a) the cytosol and (b) the nucleus of cells A and B, where the Cmedium(t = 0) was either 0.02 μM or 1 μM, and at media temperatures of 34 °C or 37 °C. These data show faster O2 diffusion into the cytosol and nucleus (i.e., lower τ values) with: (i) increasing levels of substrate strain, (ii) higher temperature of the medium, and (3) decrease in the Cmedium(t = 0)–Cc(t = 0) gradient.

7. Date of download: 11/14/2017
Copyright © ASME. All rights reserved.
From: Stretching Affects Intracellular Oxygen Levels: Three-Dimensional Multiphysics Studies
J Biomech Eng. 2012;134(6): doi: /
Figure Legend:
Time coefficients β of the exponential fits to time courses of intracellular oxygen concentrations in (a) the cytosol and (b) the nucleus of cells A and B, when there is no oxygen in the medium, and for media temperatures of 34 °C or 37 °C. These data show faster O2 diffusion out of the cytosol and nucleus (i.e., higher β values) with: (i) increasing levels of substrate strain and (ii) higher temperature of the medium.