1. From: Cardiac JAK2 Mutation V617F in a Patient with Cardiomyopathy and Myeloproliferative Disease
Ann Intern Med. 2008;149(1): doi: /
Figure Legend:
The JAK2 mutation V617F (arrowheads) is found in the patient's hypertrophic heart (a, b) and PMF-affected bone marrow (c, positive control), but wild-type JAK2 (arrow) is found in her capillary-rich thyroid (d, negative control). Laser microdissection for removal of interstitial tissue (b) had no effect on JAK2 mutational status, indicating the cardiomyocytic origin of the JAK2 mutation V617F in the heart. (Hematoxylin–eosin staining, × 200.)
Date of download: 11/13/2017
Copyright © American College of Physicians. All rights reserved.