1. They all have “Unbreakable Spirits”
Osteogenesis
Imperfecta
Chelsea Christensen
They all have “Unbreakable Spirits”

2. The Basics “Brittle Bone Disease”
Mainly caused by a collagen deficiency
Dominant, Recessive and Spontaneuous Mutations

3. Traits Shown By Most All Types have their own characteristics
General characteristics that stay the same
Short stature
Fragile skin and joints
Easy bleeding
Curve of spine

4. A Pedigree From an Amish Family

5. The Dominant Side of Things
Types I through V
Type I- most common
Type II- most severe
Type III- most severe past infant stage
Type IV- moderate
Type V- moderate

6. Rare Recessives Type VII- with total loss of cartilage it is lethal
Type VIII- severe growth deficiency
Type VI- is undetermined

7. Diagnosis of OI
Usually a clinical diagnosis based on the physician’s observations.
Collagen analysis using skin sample or DNA sequencing with a blood sample
Ultrasound may detect abnormalities at weeks, or through amniocentesis.

8. What Can Cause Breaks? Infants Rolling Burping Being picked up
Infants
Rolling
Burping
Being picked up
Children
Kicking
Jumping rope
Skipping
Adults

9. How Some Manage Life Limitations Aids No sports
Parents taught how to hold babies
Aids
Wheelchair
Crutches

10. Adulthood Normal life? Children?

11. No Cure Physical therapy Braces and casts Medicines being tested
Bisphosphonates, they include medications titled Aredia©, Fosamax©, and Reclast©

12. Child Abuse Allegations very common with OI cases
Work with your doctor to avoid allegations
Protect yourself from being listed as an abusive parent

13. Common Myths
A baby should be carried on a pillow and discouraged from moving
OI is a childhood disorder that one grows out of by their teens
All children born to parents with OI will have OI

14. Meet Leah 16-months old 70 breaks

15. Works Cited
Larocca, Felix “Ostegenesis Imperfecta and a Mother Smaller than her Infant Son”. Available:
OI Foundation “Facts about Osteogenesis Imperfecta”. Available:
OI Foundation “Types of OI”. Available:
OI Foundation “Myths about OI”. Available:
OI Foundation “Child Abuse Allegations”. Available:
MedlinePlus “Osteogenesis Imperfecta”. Avaible:
Robinson, Loretta “Family Demonstrates Unbreakable Spirit Dealing with Child’s Brittle Bone Disease”. The Muskegon Chronicle. Available: