1. New Tracers for Prostate Cancer Imaging
Stefano Fanti

2. Imaging of Prostate Cancer

4. OLD TRACERS NEW TRACERS
CURRENT TRACERS
NEW TRACERS
Many years ago, we published this work in JNM about the accuracy of PET/CT for the intra prostatic detection of cancer foci. We studied 31 patients and compared PET results with histopathology on a sextant basis.

5. Is Choline PET outdated ?

6. RECURRENCE
Patient treated with radical prostatectomy for PCa 4+4, T3bN1(2/24) MxR0, presentation PSA=12.1 ng/mL in April 2009.
Biochemical relapse occurred 11 months after surgery, with rising PSA levels (PSA 2.1 ng/mL in 10/2010).
Patient was addressed to ADT with continuous scheme (bicalutamide + LH-RH inhibitor), experiencing PSA response (PSA values <0.2 ng/mL).
In October 2012 biochemical relapse occurred with rising PSA levels during ADT .
Patient was subsequently referred to 11C- choline PET/CT with PSA value of 0.88 ng/mL, that showed a diffuse bone metastatic invasion together with lymph-node relapse.
The patient was addressed to chemotherapy (Docetaxel) according to the diffuse metastatic spread revealed by 11C-choline PET/CT.

7. Many years ago, we published this work in JNM about the accuracy of PET/CT for the intra prostatic detection of cancer foci. We studied 31 patients and compared PET results with histopathology on a sextant basis.

8. RECURRENCE
Prostatectomy
PSA 1.3 ng/Ml
DT 3 months
BS neg

9. RECURRENCE
Prostatectomy PSA 0.9 ng/mL
BS neg

10. 11C-CHOLINE

12. CHOLINE PET/CT
Many years ago, we published this work in JNM about the accuracy of PET/CT for the intra prostatic detection of cancer foci. We studied 31 patients and compared PET results with histopathology on a sextant basis.

13. CURRENT TRACERS
Many years ago, we published this work in JNM about the accuracy of PET/CT for the intra prostatic detection of cancer foci. We studied 31 patients and compared PET results with histopathology on a sextant basis.

14. PSMA TRACERS

15. 68Ga-PSMA
18F-CHOLINE

16. Images courtesy of prof Haberkorn - Heidelberg
68Ga-PSMA
18F-CHOLINE
Images courtesy of prof Haberkorn - Heidelberg

18. 392 ARTICLES SINCE 2012
128 ARTICLES IN 2017
24 ARTICLES IN MAY

19. 68Ga-PSMA

22. Only 1 exam

23. PSMA PET/CT
Many years ago, we published this work in JNM about the accuracy of PET/CT for the intra prostatic detection of cancer foci. We studied 31 patients and compared PET results with histopathology on a sextant basis.

24. Impact

25. Impact

26. NEW TRACERS

27. Fluciclovine

29. Many years ago, we published this work in JNM about the accuracy of PET/CT for the intra prostatic detection of cancer foci. We studied 31 patients and compared PET results with histopathology on a sextant basis.

30. Many years ago, we published this work in JNM about the accuracy of PET/CT for the intra prostatic detection of cancer foci. We studied 31 patients and compared PET results with histopathology on a sextant basis.

31. Detection Rate
BCR with > 1.0 PSA < 2.0

32. Detection Rate
BCR with PSA < 1.0

35. Gleason 5+4 (01/30/2007) presenting with a T2b nodule and PSA of 5.4
High grade prostate cancer involving 6/12 cores
21 months of androgen blockade
Intensity modulated pelvic XRT in 2007
PSA nadir in February 2011 was 0.11
Biochemical recurrence in 2011
MIP PET
68Ga RM2
MIP PET
68Ga PSMA
68GA-BOM
Images courtesy of prof Iagaru - Stanford

40. NEW TRACERS PET/CT
Many years ago, we published this work in JNM about the accuracy of PET/CT for the intra prostatic detection of cancer foci. We studied 31 patients and compared PET results with histopathology on a sextant basis.

42. 68GA-BOM
18F-FACBC
68GA-PSMA
11C-CHOLINE
18F-PSMA

45. Many years ago, we published this work in JNM about the accuracy of PET/CT for the intra prostatic detection of cancer foci. We studied 31 patients and compared PET results with histopathology on a sextant basis.
THANK YOU