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Presented By Marco Colleoni at 2017 ASCO Annual Meeting

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Presentation on theme: "Presented By Marco Colleoni at 2017 ASCO Annual Meeting"— Presentation transcript:

1 Presented By Marco Colleoni at 2017 ASCO Annual Meeting
SOLE (Study of Letrozole Extension)<br /><br />A phase 3 randomized clinical trial of <br />continuous vs intermittent letrozole in postmenopausal women who have received 4-6 years of adjuvant endocrine therapy for lymph node-positive, early breast cancer Presented By Marco Colleoni at 2017 ASCO Annual Meeting

2 Presented By Marco Colleoni at 2017 ASCO Annual Meeting
S LE Presented By Marco Colleoni at 2017 ASCO Annual Meeting

3 Presented By Marco Colleoni at 2017 ASCO Annual Meeting
Slide 3 Presented By Marco Colleoni at 2017 ASCO Annual Meeting

4 Presented By Marco Colleoni at 2017 ASCO Annual Meeting
Extended Adjuvant Endocrine Therapy <br />for HR+ Early Breast Cancer Presented By Marco Colleoni at 2017 ASCO Annual Meeting

5 Presented By Marco Colleoni at 2017 ASCO Annual Meeting
Alternating “on-off” Letrozole Treatment as a Therapeutic Option to Prolong Sensitivity to Endocrine Treatment Presented By Marco Colleoni at 2017 ASCO Annual Meeting

6 Presented By Marco Colleoni at 2017 ASCO Annual Meeting
Effect of intermittent letrozole treatment in <br />MCF-7Ca xenografts Presented By Marco Colleoni at 2017 ASCO Annual Meeting

7 Presented By Marco Colleoni at 2017 ASCO Annual Meeting
Questions in Extended Adjuvant Endocrine Therapy <br />in HR+ Early Breast Cancer Presented By Marco Colleoni at 2017 ASCO Annual Meeting

8 Presented By Marco Colleoni at 2017 ASCO Annual Meeting
SOLE: Study of Letrozole Extension<br />After 4 to 6 years of Prior Adjuvant Endocrine Therapy<br />Postmenopausal, HR-positive, Node-positive Presented By Marco Colleoni at 2017 ASCO Annual Meeting

9 SOLE Quality of Life Substudy
Presented By Marco Colleoni at 2017 ASCO Annual Meeting

10 Eligibility and Procedures
Presented By Marco Colleoni at 2017 ASCO Annual Meeting

11 Presented By Marco Colleoni at 2017 ASCO Annual Meeting
Endpoints Presented By Marco Colleoni at 2017 ASCO Annual Meeting

12 Statistical Considerations
Presented By Marco Colleoni at 2017 ASCO Annual Meeting

13 Presented By Marco Colleoni at 2017 ASCO Annual Meeting
Characteristics Presented By Marco Colleoni at 2017 ASCO Annual Meeting

14 Presented By Marco Colleoni at 2017 ASCO Annual Meeting
Results Presented By Marco Colleoni at 2017 ASCO Annual Meeting

15 Primary Endpoint: Disease-Free Survival
Presented By Marco Colleoni at 2017 ASCO Annual Meeting

16 Sites of First DFS Event
Presented By Marco Colleoni at 2017 ASCO Annual Meeting

17 Breast Cancer-Free Interval
Presented By Marco Colleoni at 2017 ASCO Annual Meeting

18 Distant Recurrence-Free Interval
Presented By Marco Colleoni at 2017 ASCO Annual Meeting

19 Presented By Marco Colleoni at 2017 ASCO Annual Meeting
Overall Survival Presented By Marco Colleoni at 2017 ASCO Annual Meeting

20 Presented By Marco Colleoni at 2017 ASCO Annual Meeting
Treatment Presented By Marco Colleoni at 2017 ASCO Annual Meeting

21 Selected Adverse Events: Worst Grade
Presented By Marco Colleoni at 2017 ASCO Annual Meeting

22 Quality of Life:<br />Change from Baseline to 12 and 24 Months
Presented By Marco Colleoni at 2017 ASCO Annual Meeting

23 Presented By Marco Colleoni at 2017 ASCO Annual Meeting
SOLE: Conclusions Presented By Marco Colleoni at 2017 ASCO Annual Meeting

24 Presented By Marco Colleoni at 2017 ASCO Annual Meeting
SOLE: Conclusions Presented By Marco Colleoni at 2017 ASCO Annual Meeting

25 Presented By Marco Colleoni at 2017 ASCO Annual Meeting
IBCSG Thanks Presented By Marco Colleoni at 2017 ASCO Annual Meeting

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