1. Rule #1
Use commas to separate three or more words, phrases, or clauses written in a series.
Example: My brother has curly hair, green eyes, and a silly laugh.

2. Rule #2
Use commas to separate independent clauses when they are joined by any of the seven coordinating conjunctions. (BOYFANS or FANBOYS)

3. Rule #2 Examples
But I really don’t want to do my homework, but I want to pass my classes.
Or I could come pick you up, or I could meet you there.
Yet I hate pickles, yet I love them when they are fried.
For I love my younger brother, for he can always make me laugh.
And He went to see The Fault in Our Stars, and he cried the entire time.
Nor I don’t like waking up early, nor do I like going to bed early.
So I didn’t feel the greatest, so I ended up staying at home.

4. Rule #3
Use commas after introductory phrases, clauses, or words that come before the main clause.
Example: After waiting in line for hours, they told us that the ride was closed because it had broken down.

5. Rule #4
Use a pair of commas in the middle of a sentence to set off phrases that are not essential to the meaning of the sentence. (Appositives)
My favorite teacher in the entire world, Ms. Norton, is hilarious.

6. Rule #5
Use commas to separate two or more adjectives that describe the same noun.
Example: The loud, annoying guy should go home.

7. Rule #6
Use commas to set off all geographical names, items in addresses, and titles in names.
Examples: I lived in Mamers, North Carolina for eighteen years.

8. Rule #7
Use commas to separate a direct quote from the rest of the sentence.
Example: Ms. Norton asked, “Who is ready for the weekend?” “We are,” the classes responds

9. Rule #8
Use commas wherever necessary to prevent possible confusion or misreading.
Example: To Ms. Norton, Taylor Swift is the best performer.

10. Rule #9
Use commas before or surrounding the name or title of a person directly addressed.
Will you, Emma, take Greg to be your lawfully wedded husband?

11. Rule #10 Use a comma to separate a statement from a question.
Example: I can do this, can’t I?

12. Rule #11 Use a comma to separate contrasting parts of a sentence.
Example: This is my life, not yours.

13. Rule #12
Use a comma when beginning sentences with introductory words such as well, now, or yes.
Well, I would love to go to the movies with you.

14. Rule #13
Use commas surrounding words such as therefore and however when they used as interrupters.
Example: I would, however, prefer not to see a scary movie.