1. Oncogene activation Transcription DNA damage MDM2 CDKN2A MDM4 p53 ATR
miR-221/222; miR-26ab/1297; miR-208/208ab; miR-499/499-5p; miR-10; miR-194; miR-24
MDM2
CDKN2A
miR-9; miR-128; miR-365; miR-125/351
miR-130/301; miR-19; miR-7/7ab; miR-183; miR-191; miR-216/216b; miR-17-5p/20/93.mr/106/519.d; miR-199/199-5p; miR-122; miR-137; miR-129/129-5p; miR-10
MDM4
miR-150; miR-27ab; let-7/98; miR-125/351; miR-338/338-3p; miR-143; miR-19; miR-148/152; miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-218; miR-22; miR-128; miR-219/219-5p; miR-24; miR-141/200a; miR-25/32/92/92ab/363/367; miR-223
p53
Transcription
ATR
CHEK1
CHEK2
miR-383; miR-146; miR-132/212
miR-15/16/195/424/497; miR-7/7ab; miR-503
ATM
DNA damage
miR-181; miR-26ab/1297; miR-18ab; miR-203; miR-193ab; miR-141/200a; miR-217; miR-106/302; miR-194; miR-383; miR-129/129-5p; miR-214/761; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-132/212; miR-143; miR-182; miR-208/208ab; miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-101; miR-21/590-5p; miR-192/215 ;miR-338/338-3p; miR-499/499-5p; miR-10; miR-130/301; miR-375; miR-122; miR-221/222; miR-425/489; miR-17-5p/20/93.mr/106/519.d; miR-150; miR-103/107; miR-216/216a; miR-96/1271; miR-216/216b; miR-204/211; miR-24
Supplemental Figure 5. Overview of p53 signaling.
Summary of p53 signaling and predicted miRNA interactions. miRNAs that were described to be downregulated in bladder cancer are highlighted in green, while upregulated miRNAs are highlighted in red; all other potential interactions are highlighted in black. Target interactions were predicted with TargetScan 5.1. miRNAs presented in this figure are all highly conserved among vertebrates; for a list of other miRNAs see Supplement Table 6.