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The see-saw of Keap1-Nrf2 pathway in cancer

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Presentation on theme: "The see-saw of Keap1-Nrf2 pathway in cancer"— Presentation transcript:

1 The see-saw of Keap1-Nrf2 pathway in cancer
Poorti Pandey, Alok Kumar Singh, Mritunjai Singh, Mallika Tewari, Hari Shankar Shukla, Indrajeet Singh Gambhir  Critical Reviews in Oncology / Hematology  Volume 116, Pages (August 2017) DOI: /j.critrevonc Copyright © Terms and Conditions

2 Fig 1 Flow diagram showing factors involved in ROS generation and cascade of events in detoxification. Critical Reviews in Oncology / Hematology  , 89-98DOI: ( /j.critrevonc ) Copyright © Terms and Conditions

3 Fig. 2 Structural domains and their functions (A) KEAP1 (B) NRF2.
Critical Reviews in Oncology / Hematology  , 89-98DOI: ( /j.critrevonc ) Copyright © Terms and Conditions

4 Fig. 3 Stepwise mechanism of Keap1 mediated protection and repression during stressed and unstressed condition. Critical Reviews in Oncology / Hematology  , 89-98DOI: ( /j.critrevonc ) Copyright © Terms and Conditions

5 Fig. 4 Various Mutations in different domains of Keap1 available at CBIO Portal. Critical Reviews in Oncology / Hematology  , 89-98DOI: ( /j.critrevonc ) Copyright © Terms and Conditions


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