1. Autoimmune Cerebellar Ataxia Cerebellum Mrs. Ramirez

2. Cerebellum Location
Cerebellum is located behind the top part of the brain stem
Under the temporal and occipital lobes
Where the spinal cord meets the brain, made of two hemispheres or halves

3. Functions Controlled by Cerebellum
Receives information from the sensory systems, the spinal cord, and other parts of the brain and then regulates motor movements
coordinates voluntary movements such as posture, balance, coordination, and speech, resulting in smooth and balanced muscular activity
Important for learning motor behaviors

5. Autoimmune Cerebellar Ataxia
Comes on rapidly and progresses quickly
Can be divided into disorders that are paraneoplastic (triggered by cancer in the body) or non-paraneoplastic (non-cancer- related autoimmune disorders of the central nervous system)
Non-cancer-related autoimmune disorder
Body produces antibodies that destroy neurons located in the cerebellum

6. ACA - Stiff Person Syndrome
Initial stage of the disease, the patient has an exaggerated upright posture and may report back discomfort or stiffness or pain in the entire back, which is worse with tension or stress.
The patient begins to move very slowly because rapid movement induces severe spasms.
Depression has been noted as a comorbidity during the late stage of the disease. The patient's quality of life is affected severely at this point, making it difficult or impossible to drive, work, or have a satisfying social life.

7. Autoimmune Cerebellar Ataxia
Disabling neurological effects
which can include speech,
eye movement
Balance
unsteady walk
difficulties when swallowing

8. Autoimmune Cerebellar Ataxia
Effects can include speech that is not clearly articulated
gait
balance disorders
loss of muscle control in the limbs

9. Treatment of Autoimmune Cerebellar Ataxia
Response to immunotherapy
56 patients used a wheelchair
26 patients had walkers
7 patients used canes
25 of them required no gait aid but had an abnormal gait
4 patients had normal gait

10. Treatment of Autoimmune Cerebellar Ataxia
Stem Cell Transplants currently being done in other countries outside of the USA
Stem cells removes from CSF and transplanted in affected region

11. Work Cited Slide Autoimmune cerebellar ataxia
Stiff Person Syndrome Clinical Presentation
Autoimmune Cerebellar Ataxia May Respond to Immunotherapy Responses to Treatment, Outcomes of Autoimmune Cerebellar Ataxia autoimmune-cerebellar-ataxia/