1. Prescription Decision Support For Primary Care
Kevin Mayes, CEO
October 2016

2. High Cholesterol

3. Extensive Metabolizer
Acid Reflux
Poor
Metabolizer
Extensive Metabolizer
CYP2C19
Gene
Lansoprazole
Omeprazole
Pantoprazole
Esomeprazole
Rabeprazole

4. Commonly Prescribed

5. Pharmacogenomics (PGx)
Will this drug work?
Avoid expensive meds the patient won’t respond to
How fast will it metabolize?
Calibrate effective dose without trial and error
What side effects will occur?
Ensure patient compliance and avoid serious events

6. Gap between promise and reality
98% of physicians believe genetics influence prescribing
only 13% are comfortable ordering a test

7. Why? Knowledge Barriers Use Case Barriers
new research articles published every week
Difficulty understanding clinical relevance of evidence
No way to interpret the raw genetic information
Knowledge Barriers
Use Case Barriers
Tests expensive, rarely reimbursed
Decision made at point of care, but tests take weeks
No time to interpret complex reports

8. Our Co-founders Discovered many drug-on-gene correlations
MARK RATAIN, M.D.
PETER H. O’DONNELL, M.D.
Discovered many drug-on-gene correlations
Frustrated that PGx wasn’t translating to clinical use
Founded Center for Personalized Therapeutics at University of Chicago
Created the Genomic Prescribing System (GPS)
4+ years and $4MM in grants
Rigorously tested “1,200 Patients Project”
20 physicians, 8 specialties, 4,000+ encounters to date

9. Research Backed Solution
Study Results
Clinical efficacy demonstrated in published research
~90% patients had 1+ PGx drug
Physician embraced
85% felt made better decision
Market interest demonstrated by physicians requesting to use GPS in their own practice
PrescriptIQ founded to address market demand
Incubated at Polsky Center
Study physicians among its launch customers

10. About Us
SAAS-based clinical decision support software for primary care
Gene-on drug interactions
Medication cost
Drug-on-drug interactions
Drug-on-drug-on-gene interactions
Integrated into physician workflow via web-based interface & EMR
Single, proprietary & preemptive genomic test provided by CLIA lab

11. Market Traction Early-adopter customers International interest
2 concierge physician practices
2 large academic health systems (Stanford & UCSF)
Searching for health system pilot
International interest
Singapore, Japan and China
Seed round in progress ($450K of $650K raised)
Building leadership team
Goal: demonstrate evidence to achieve reimbursement

12. Thank you!