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Large-Animal Models of Acute Respiratory Distress Syndrome

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Presentation on theme: "Large-Animal Models of Acute Respiratory Distress Syndrome"— Presentation transcript:

1 Large-Animal Models of Acute Respiratory Distress Syndrome
Cherry Ballard-Croft, PhD, Dongfang Wang, MD, PhD, L. Ryan Sumpter, MS, Xiaoqin Zhou, MD, Joseph B. Zwischenberger, MD  The Annals of Thoracic Surgery  Volume 93, Issue 4, Pages (April 2012) DOI: /j.athoracsur Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Repeated lavage model. Light microscopy of pig lungs after repeated lavage shows perivascular edema and a thickened alveolocapillary membrane. (A) ×200 magnification; (B) ×500 magnification. (Reprinted from Kucklet et al, Exp Pathol 1981;20:88–104 [35], with permission from Elsevier.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Oleic acid model. Twelve hours after oleic acid administration, septal necrosis and neutrophil infiltration is evident (hematoxylin-eosin stain, ×250 magnification). (Reprinted from Derks and Jacobovitz-Derks, Am J Pathol 1977;87:143–58 [47], with permission from Elsevier.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Endotoxin model. (A) A 50 μg/kg exposure of lipopolysaccharide damaged the capillary endothelium. Arrowhead indicates edematous cuff around a pulmonary vessel (scale bar, 100 μm). (B) A 25 μg/kg lipopolysaccharide dosage caused alveolar edema as indicated by the arrowhead. Neutrophil infiltration into alveolar lumen is also present (scale bar, 25 μm). (Reprinted from Picone et al, Shock 1996;5:304–10 [61], with permission from Lippincott, Williams and Wilkins.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Smoke/burn model. After smoke/burn injury, congestion, hemorrhage, edema, leukocytic infiltration, and septal thickening are evident. (A) ×200 magnification; (B) ×400 magnification. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

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