1. Device for Shielding a Neurochemical Sampling Apparatus
Mark Reagan
Anika Lohrentz
David Leinweber
Alison Boumeester
Client: Ei Terasawa, Ph.D
Advisor: Naomi Chesler, Ph.D

2. Outline Background Design Objectives Previous Work New Designs
Design Matrix
Ski Mask
Bone Screws
Reverse Cone
Final Design

3. Background Neurochemical collection from Rhesus macaques
Microdrive inserted into brain
Confined to chairs
12 hour duration, every month
Free movement preferable

4. Design Objectives Protect microdrive Safe Lightweight Easy to use
Production
Cost- $1000 Budget
Forst SI, et al., Microdialysis methods for in vivo neropeptide measurement in the Stalk-median eminence in the Rhesus monkey, J Neurosci Methods (2007).

5. Previous Work
Spring 2008
Strap did not work
Fall 2008
Too heavy

6. Design Ideas
Ski Mask
Bone Screws
Reverse Cone

7. Ski Mask Pros Cons Minimal volume Aesthetically pleasing
Excessive wiggle room
Complex set up
Weight focused well above head

8. Bone Screws Pros Cons Most stable attachment method
Invasiveness adds risk, administrative hurdles
Juvenile skulls very thin
Attachment points not absolute

9. Reverse Cone Pros Cons Ample clearance around microdrive
Light weight, carried close to body
Compatible with growing subjects
Readily approvable and producible
Cons
Reaching into cone
Monkey-proofing face hole

10. Design Matrix Category Weight Bone Screws Ski Mask Reverse Cone Safety40 30 25 35
Ease of Implementation 10 28
Practicality of Production 20 15 18
Comfort 5 7 8
Total 60 67 89

11. Final Design Reverse Cone “Hospital” neck brace for support
Lining for “Head Cutout”: Suction Molding

12. Questions?