1. Dopamine metabolism results in hydrogen peroxide (H2O2) formation
Dopamine metabolism results in hydrogen peroxide (H2O2) formation. If the glutathione system is deficient or excess hydrogen peroxide is present, hydrogen peroxide accepts an electron from ferrous iron (Fe2+), forming ferric iron (Fe3+), and the hydroxyl free radical (OH*). The hydroxyl free radical can cause lipid peroxidation, thereby damaging neuronal cell membranes. (DOPAC, 3,4-dihydroxyphenylacetic acid; GSH, glutathione; GSSG, glutathione disulfide; H2O, water; OH−, the hydroxide ion; MAO-B, monoamine oxidase B.)
Source: Chapter 43. Parkinson's Disease, Pharmacotherapy: A Pathophysiologic Approach, 9e
Citation: DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey L. Pharmacotherapy: A Pathophysiologic Approach, 9e; 2014 Available at: Accessed: October 28, 2017
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