1. Evidence-based survey of the elimination rates of ethanol from blood with applications in forensic casework 
Alan Wayne Jones 
Forensic Science International 
Volume 200, Issue 1, Pages 1-20 (July 2010)
DOI: /j.forsciint
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2. Fig. 1
Human metabolism of ethanol illustrating oxidative and non-oxidative pathways and the relative amounts excreted unchanged. The CYP2E1 enzyme has a higher km for ethanol as substrate compared with ADH and becomes more important in metabolism when blood-alcohol concentration exceeds 60mg/100mL.
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3. Fig. 2
Pharmacokinetic profile of ethanol showing a rising BAC (absorption) to reach a peak concentration (Cmax) at time tmax followed by a rectilinear declining phase (zero-order kinetics). Linear regression analysis gives the y-intercept (C0) and x-intercept (min0) allowing determination of the elimination rate from blood (β-slope) and distribution volume (rho factor) as shown.
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4. Fig. 3
Food-induced lowering of blood-alcohol curves when healthy subjects (N=12) drank a moderate dose (0.8g ethanol/kg body weight) on an empty stomach or after eating a standardized breakfast. The insert graph shows the curves for a single subject [71].
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5. Fig. 4
Negative correlation between the elimination rate of alcohol from blood (β) and the distribution volume of ethanol (rho) in healthy men and women who consumed alcohol on an empty stomach.
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6. Fig. 5
Inter-individual variations in shapes of the concentration–time profiles of ethanol in 48 healthy men after they drank 0.68g/kg body weight as neat whisky in the morning after an overnight fast [65].
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7. Fig. 6
Intra-individual variations in concentration–time profiles of ethanol in 4 subjects after they drank a dose of 0.80g/kg body weight on an empty stomach on four separate occasions [112].
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8. Fig. 7
No statistically significant differences in mean elimination rate of ethanol from blood between and within subjects according to one-way analysis of variance. Results are for 12 subjects who drank 0.80g ethanol per kg body weight on four separate occasions [112].
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9. Fig. 8
Concentration–time profiles of ethanol during the post-absorptive portions of blood-alcohol curve in the same male subject (aged 24 years) who drank alcohol (0.5g/kg) on 10 separate occasions [113].
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10. Fig. 9
Relative frequency distribution of blood-alcohol concentrations among apprehended drivers in Sweden.
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11. Fig. 10
Relative frequency distribution of elimination rates of alcohol from blood in apprehended drivers derived from double blood samples taken ∼1h apart [16].
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12. Fig. 11
Concentration–time profiles of alcohol in blood in four alcoholics during detoxification showing how the elimination rate of ethanol from blood was determined by linear regression analysis [121].
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