1. Supplementary Table 1 Independent Predictors of 2-Year Mortality
Parameter
Hazard Ratio (95% CI)
p-value
CTE (Overall)
3.3 ( )
<0.001
PP CTE
1.5 ( )
0.36
Non-PP MI
3.7 ( )
Non-PP ST
3.7 ( )
0.002
AB (Overall)
3.5 ( )
PP AB
2.5 ( )
0.052
Non-PP BARC type 2
2.6 ( )
Non-PP BARC type 3
5.2 ( )
Age (per 1 year increase)
1.03 ( )
Prior MI
1.53 (1.1 – 2.1)
0.01
Female sex
0.70 ( )
0.04
Europe (vs. US)
0.64 ( )
BMS (vs. DES)
1.8 ( )
0.001
Current smoking
2.1 ( )
DM (non-Insulin requiring)
1.6 ( )
DM (Insulin requiring)
1.9 ( )
CrCl < 45 ml/min/1.73m2
2.7 ( )
Hemoglobin (per 1 mg/dl increase)
0.83 ( )
BMI ≥ 35 (versus BMI < 25)
1.7 ( )
Hazard ratios generated from fully fitted models with CTE and AB entered as hierarchical time-varying covariates. CTE – coronary thrombotic event; AB – actionable bleeding; DM – diabetes mellitus; ACS – acute coronary syndrome; BMS – bare metal stent; DES – drug eluting stent; CrCl– creatinine clearance; PP- periprocedural; BMI – body mass index; MI – myocardial infarction

2. Supplementary Table 2 Mortality Hazard Ratios (95% CI) After Excluding Patients with Both Coronary Thrombotic Events and Actionable Bleeding
HR (95% CI)
Deaths, n
CTE (Overall)
3.8 (2.3 – 6.4) 21
PP CTE
1.2 ( ) 4
Non-PP MI
5.8 ( ) 10
Non-PP ST
8.7 (3.4 – 22.3) 7
AB (Overall)
3.4 ( ) 36
PP AB
1.6 ( ) 3
Non-PP BARC type 2
2.1 (0.9 – 4.6) 11
Non-PP BARC type 3
7.3 ( ) 22
CTE – coronary thrombotic event; AB – actionable bleeding; HR-hazard ratio; CI- confidence interval; PP – periprocedural; BARC – Bleeding Academic Research Consortium

3. Supplementary Table 3 Mortality Hazard Ratios (95% CI) Using Cardiac Death as Dependent Outcome
HR (95% CI)
Deaths, n
CTE (Overall)
4.5 (2.9 – 7.2) 34
PP CTE
2.5 ( ) 7
Non-PP MI
5.4 ( ) 19
Non-PP ST
4.7 (1.8 – 12.3) 8
AB (Overall)
2.8 ( ) 32
PP AB
2.8 ( ) 4
Non-PP BARC type 2
1.8 (0.7 – 4.3) 6
Non-PP BARC type 3
3.7 ( ) 22
CTE – coronary thrombotic event; AB – actionable bleeding; HR-hazard ratio; CI- confidence interval; PP – periprocedural; BARC – Bleeding Academic Research Consortium

4. Proportion of Deaths In Discrete Time Intervals After CTE or AB
Supplementary Figure 1