1. Supplementary Appendix

2. 0 5 10 15 20 25 30 01234567891011 Thrombotic Risk Scores % of Patients Risk Categories Low Risk (n=3491) Intermediate Risk (n=2806) High Risk (n=1833) Distribution of Thrombotic Risk Score in ADAPT DES Patients Supplementary Figure 1A

3. 0 5 10 15 20 25 012345678910111213 Bleeding Risk Scores % of Patients Risk Categories Low Risk (n=4394) Intermediate Risk (n=3276) High Risk (n=460) Distribution of Bleeding Risk Score in ADAPT DES Patients Supplementary Figure 1B

4. Log Rank p < 0.0001 0 2 4 6 8 9 016121824 Months since PCI Cumulative Incidence (%) Risk Categories Low Risk 1.11% (37) Intermediate Risk 3.00% (79) High Risk 8.49% (144) Rates of Coronary Thrombotic Events at 2 Years by Level of Thrombotic Risk Supplementary Figure 2A

5. 2016-01-21 Log Rank p < 0.0001 0 2 4 6 8 10 016121824 Months since PCI Risk Categories Low Risk 2.36% (96) Intermediate Risk 4.45% (135) High Risk 9.35% (39) Cumulative Incidence (%) Rates of Major Bleeding at 2 Years by Level of Bleeding Risk Supplementary Figure 2B

6. Supplementary Table Associations Between Clinical Parameters and Thrombotic and Bleeding Events After Inclusion of DAPT Cessation in Each Model Parameter Coronary Thrombotic Event HR (95% CI) Major Bleeding HR (95% CI) Age, per year increase1.07 (1.0-1.04) BMI < 25, kg/m 2 1.65 (1.07-2.56) BMI > 35, kg/m 2 1.79 (1.04-3.08) Anemia2.59 (1.79-3.75) Triple therapy on discharge1.84 (1.02-3.31) Current smoking1.63 (1.06-2.50)1.89 (1.15-3.12) CrCl < 60 ml/min2.02 (1.42-2.87) Diabetes Mellitus Non-insulin requiring1.69 (1.14-2.52) Insulin Requiring3.40 (2.31-5.02) Acute Coronary Syndrome Troponin negative1.34 (0.94-1.91) Troponin positive2.20 (1.31-3.72) Prior PCI1.89 (1.36 -2.62) Prior CABG1.87 (1.29-2.71) BMI- body mass index; PCI-percutaneous coronary intervention; CABG-coronary artery bypass graft; HR – hazard ratio; CI – confidence interval; DAPT – dual antiplatelet therapy. HR (95% CI) generated from multivariable Cox models that include DAPT cessation as a time- varying covariate