Presentation is loading. Please wait.

Presentation is loading. Please wait.

Fig. 1 Changes in biochemical assessment of CKD-MBD over time: Cy/+ rats were treated with diet only (CKD CTL), R-568, R-568 + Ca or calcium alone (Ca).

Published byJudith Woods Modified over 6 years ago

Similar presentations

Presentation on theme: "Fig. 1 Changes in biochemical assessment of CKD-MBD over time: Cy/+ rats were treated with diet only (CKD CTL), R-568, R-568 + Ca or calcium alone (Ca)."— Presentation transcript:

1 Fig. 1 Changes in biochemical assessment of CKD-MBD over time: Cy/+ rats were treated with diet only (CKD CTL), R-568, R Ca or calcium alone (Ca). (A) PTH increased over time in the control animals but was equally suppressed by all three treatments (P < ). (B) The calcium level was increased in the Ca-treated animals and decreased in the R-568-treated animals (each P < 0.001). In contrast, the addition of calcium to R-568 normalized the calcium to that of the control animals. (C) Phosphorus levels decreased very slightly in the control animals until after 34 weeks when there was an increase with further decline in renal function and increase in PTH. The animals treated with R Ca or Ca alone had a significant decrease in phosphorus compared to control at 38 weeks (P < 0.001). In contrast, the R-568-treated animals had an increase in the plasma phosphorus at 29 and 34 weeks compared to control, with a return to control levels at 38 weeks (P < 0.001). Solid black bars = CKD animals without treatment (control); open white bars = CKD given R-568; hatched bars = CKD animals given R-568 plus 2% calcium gluconate in the drinking water; grey bars = CKD animals given only 2% calcium gluconate in the drinking water. The number of animals at each time point was 31–33 at 20 weeks, 15–16 at 29 weeks, 29–32 at 34 weeks and 15–16 at 38 weeks. From: R-568 reduces ectopic calcification in a rat model of chronic kidney disease-mineral bone disorder (CKD-MBD) Nephrol Dial Transplant. 2009;24(8): doi: /ndt/gfp078 Nephrol Dial Transplant | Published by Oxford University Press on behalf of ERA-EDTA [2009]. All rights reserved. For Permissions, please University Press

2 Fig. 2 Thoracic aorta calcification
Fig. 2 Thoracic aorta calcification. At the time of sacrifice, the thoracic aorta was removed and its calcium and phosphorus content determined biochemically. At 34 weeks, there was no difference in the calcium content (A), but the phosphorus content (B) was greater in the calcium-treated animals than all of the other groups (P = 0.002). At 38 weeks, the calcium-treated animals had greater calcium (P = 0.04; A) and phosphorus content (P = 0.03; B) compared with the R-568-treated animals. At 38 weeks, animals treated with R Ca had higher calcium content than R-568 alone. Solid black bars = CKD animals without treatment (control); open white bars = CKD given R-568; hatched bars = CKD animals given R-568 plus 2% calcium gluconate in the drinking water; grey bars = CKD animals given only 2% calcium gluconate in the drinking water. From: R-568 reduces ectopic calcification in a rat model of chronic kidney disease-mineral bone disorder (CKD-MBD) Nephrol Dial Transplant. 2009;24(8): doi: /ndt/gfp078 Nephrol Dial Transplant | Published by Oxford University Press on behalf of ERA-EDTA [2009]. All rights reserved. For Permissions, please University Press

3 Fig. 3 Aortic arch calcification
Fig. 3 Aortic arch calcification. The aortic arch was dissected from above the aortic valve to the ligamentum arteriosum from either 34- or 38-week animals and its calcium (A) and phosphorus (B) content analysed biochemically (n = 6–8 per group). The results are expressed as μmol/g of tissue. At 34 and 38 weeks (A), there was a trend for a reduction in calcium content in R-568-treated animals compared with calcium alone, but this did not reach statistical significance. At 34 weeks (B), there was no difference in the phosphorus content. In contrast, at 38 weeks, there was increased phosphorus content in the rats treated with calcium alone compared with the other treatment groups (P = 0.004). Solid black bars = CKD animals without treatment (control); open white bars = CKD given R-568; hatched bars = CKD animals given R-568 plus 2% calcium gluconate in the drinking water; grey bars = CKD animals given only 2% calcium gluconate in the drinking water. From: R-568 reduces ectopic calcification in a rat model of chronic kidney disease-mineral bone disorder (CKD-MBD) Nephrol Dial Transplant. 2009;24(8): doi: /ndt/gfp078 Nephrol Dial Transplant | Published by Oxford University Press on behalf of ERA-EDTA [2009]. All rights reserved. For Permissions, please University Press

4 Fig. 4 Heart calcification
Fig. 4 Heart calcification. The upper atrium/aortic valve (A) and left ventricle (B) from either 34- or 38-week animals was isolated and the calcium content analysed biochemically (n = 6–8 per group). The results are expressed as μmol/g of tissue. At 34 weeks for the aortic valve (A), there was a trend towards less calcium (P = 0.053) in the R-568 alone treated animals, and by 38 weeks, both calcium-treated groups had more calcium content than the R-568-treated animals and controls (P = 0.035). The left ventricle (B) had less calcium at 34 weeks (P = 0.008) and 38 weeks (P = 0.005) in the R-568 alone treated animals than in the other treatment groups. Solid black bars = CKD animals without treatment (control); open white bars = CKD given R-568; hatched bars = CKD animals given R-568 plus 2% calcium gluconate in the drinking water; grey bars = CKD animals given only 2% calcium gluconate in the drinking water. From: R-568 reduces ectopic calcification in a rat model of chronic kidney disease-mineral bone disorder (CKD-MBD) Nephrol Dial Transplant. 2009;24(8): doi: /ndt/gfp078 Nephrol Dial Transplant | Published by Oxford University Press on behalf of ERA-EDTA [2009]. All rights reserved. For Permissions, please University Press

Download ppt "Fig. 1 Changes in biochemical assessment of CKD-MBD over time: Cy/+ rats were treated with diet only (CKD CTL), R-568, R-568 + Ca or calcium alone (Ca)."

Similar presentations

Uncontrolled secondary hyperparathyroidism in a haemodialysis patient Jordi Bover, MD, PhD Fundació Puigvert Barcelona, Spain © Springer Healthcare, a.

Uncontrolled secondary hyperparathyroidism in a haemodialysis patient Jordi Bover, MD, PhD Fundació Puigvert Barcelona, Spain © Springer Healthcare, a.
Fig. 1. Flow diagram of study participants and outcomes.

Fig. 1. Flow diagram of study participants and outcomes.
Oral Phosphate Binders in Patients with Kidney Failure

Oral Phosphate Binders in Patients with Kidney Failure
From: An open day in the metric space

From: An open day in the metric space
Figure 1. Estimated marginal mean (+/− SE) QSU-B factor 1 craving scores for the three-way interaction of Quitting Intention by Expect by Administered.

Figure 1. Estimated marginal mean (+/− SE) QSU-B factor 1 craving scores for the three-way interaction of Quitting Intention by Expect by Administered.
Volume 69, Issue 1, Pages (January 2006)

Volume 69, Issue 1, Pages (January 2006)
Fig 1 Trends in organ donors in the UK, 2000–10

Fig 1 Trends in organ donors in the UK, 2000–10
Fig. 1 ( A ) COX-2 mRNA abundance in hVSMC incubated without (−) and with (+) fetal calf serum (FCS, 2 h) and vehicle (control), cyclosporine A (CsA 100.

Fig. 1 ( A ) COX-2 mRNA abundance in hVSMC incubated without (−) and with (+) fetal calf serum (FCS, 2 h) and vehicle (control), cyclosporine A (CsA 100.
Fig. 3. Quantitative analysis of calcification at the aortic root showing the effect of long-term PD administration of PPi in mice . ( A ) Calcification.

Fig. 3. Quantitative analysis of calcification at the aortic root showing the effect of long-term PD administration of PPi in mice . ( A ) Calcification.
Fig. 1. Architectural limitations (dark grey area) and functional limitation (light grey filled with forward diagonal lines) of canopy photosynthesis rate.

Fig. 1. Architectural limitations (dark grey area) and functional limitation (light grey filled with forward diagonal lines) of canopy photosynthesis rate.
Fig. 1. Serum activity of the osteoclast-specific enzyme TRAP-5b and serum levels of RANKL and OPG, key regulators involved in osteoclast differentiation.

Fig. 1. Serum activity of the osteoclast-specific enzyme TRAP-5b and serum levels of RANKL and OPG, key regulators involved in osteoclast differentiation.
FIGURE 1 Bivariate relationship between serum urea levels and serum Hcit levels, according to different nutritional regimens, namely FD, MD and VLPD. From:

FIGURE 1 Bivariate relationship between serum urea levels and serum Hcit levels, according to different nutritional regimens, namely FD, MD and VLPD. From:
FIGURE 1 Flow chart of the study population

FIGURE 1 Flow chart of the study population
Figure 1. Least square means of the swimming speed procedures, over a 6-month time period (24–30 months). Longevity was significantly predicted by higher.

Figure 1. Least square means of the swimming speed procedures, over a 6-month time period (24–30 months). Longevity was significantly predicted by higher.
Fig. 4 Glucose concentration in the first 3 h of the dialysis session (blue circles) or equivalent time of the following day without dialysis (red circles).

Fig. 4 Glucose concentration in the first 3 h of the dialysis session (blue circles) or equivalent time of the following day without dialysis (red circles).
FIGURE 1: The flow chart of the systematic review: paper retrieval and selection. From: Pregnancy in dialysis patients in the new millennium: a systematic.

FIGURE 1: The flow chart of the systematic review: paper retrieval and selection. From: Pregnancy in dialysis patients in the new millennium: a systematic.
Fig. 1. Age-dependent distribution of AKI risk factors

Fig. 1. Age-dependent distribution of AKI risk factors
FIGURE 1: Plasma levels of indoxyl sulfate (IS) in four groups: Sham, Sham + AST-120, CKD and CKD + AST-120 mice (n = 12 for each group). Data are expressed.

FIGURE 1: Plasma levels of indoxyl sulfate (IS) in four groups: Sham, Sham + AST-120, CKD and CKD + AST-120 mice (n = 12 for each group). Data are expressed.
FIGURE 1 Flow chart of patient inclusion.

FIGURE 1 Flow chart of patient inclusion.
Figure 1. Percentage of trainees is represented on the y-axis for each competency/knowledge item represented in the x-axis. Only Poor/Fair (P/F) ratings.

Figure 1. Percentage of trainees is represented on the y-axis for each competency/knowledge item represented in the x-axis. Only Poor/Fair (P/F) ratings.

Similar presentations

Ads by Google