1. Figure 1. Least square means of the swimming speed procedures, over a 6-month time period (24–30 months). Longevity was significantly predicted by higher baseline swim speed (hazard ratio 0.88 for 1 cm/s increase; 95% confidence interval 0.81–0.97; p = .009),
From: Usefulness of Preclinical Models for Assessing the Efficacy of Late-Life Interventions for Sarcopenia
J Gerontol A Biol Sci Med Sci. 2011;67A(1): doi: /gerona/glr042
J Gerontol A Biol Sci Med Sci | © The Author Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please

2. Figure 2. Latency to fall (a) from an incline plane in 24-month-old F344BN male rats that were wheel running for 2 weeks (n = 20) or were sedentary (n = 19). *p = .04 for difference from a wheel-running group by t test. (b) Correlation between latency to fall from an incline plane and body weight, p = .037, r² = .112.
From: Usefulness of Preclinical Models for Assessing the Efficacy of Late-Life Interventions for Sarcopenia
J Gerontol A Biol Sci Med Sci. 2011;67A(1): doi: /gerona/glr042
J Gerontol A Biol Sci Med Sci | © The Author Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please

3. Figure 3. Young and old F344BN rats were fed rapamycin for 3 weeks or were given a regimen of intermittent (every other day) calorie restriction (IF). IF- and rapamycin-treated animals lost approximately 15% of their body weight relative to controls. Moreover, the young IF animals lost more weight than their rapamycin-fed counterparts (lower panel). There was an effect of age on the memory test (upper right); however, rapamycin had no impact on cognitive function, although physical activity was increased with treatment, regardless of age (*all ps < .05).
From: Usefulness of Preclinical Models for Assessing the Efficacy of Late-Life Interventions for Sarcopenia
J Gerontol A Biol Sci Med Sci. 2011;67A(1): doi: /gerona/glr042
J Gerontol A Biol Sci Med Sci | © The Author Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please

4. Figure 4. Four weeks of low-intensity exercise (12 cm/s; 10 combined with low-dose enalapril treatment (20 mg/kg/d) administered to 24-month-old male F344BN rats results in additional weight loss and greater endurance relative to enalapril treatment alone (*p < .05).
From: Usefulness of Preclinical Models for Assessing the Efficacy of Late-Life Interventions for Sarcopenia
J Gerontol A Biol Sci Med Sci. 2011;67A(1): doi: /gerona/glr042
J Gerontol A Biol Sci Med Sci | © The Author Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please