1. Chromosomal Disorders Nondisjunction

2. Down Syndrome Life Expectancy 55 yrs

3. Frequency of Down Average 1:700 Births
/1400
/1100
/900
/100
/25

4. Edward’s Syndrome Trisomy 18
1:6,000 Births
Second most common after Down Syndrome

5. Patau Syndrome Trisomy 13
1:12,000 Births
> 80% die in first year

6. 1:50,000

7. Turner Syndrome 45,X
1:2,500 Births

8. Klinefelter Syndrome 47, XXY
tall, longer arms than legs
1: :1000
no or low testosterone
male reproductive organs under developed
no sperm production
develop some breast tissue

9. 47, XYY Super Male

10. Triple X 47, XXX
Skin folds that descend and cover the inner corners of the eyes
Wide spacing between the eyes
Decreased muscle tone (hypotonia)
Curved fifth ("pinky") fingers
Small head circumference
Learning disabilities, such as delayed speech and language development, and difficulty reading
Delayed motor skills, such as sitting and walking
Problems processing sound
Behavioral and emotional problems, including attention deficit hyperactivity disorder (ADHD), anxiety, and depression
Premature ovarian failure or ovary malformations (though infertility is rare)
Menstrual irregularities