1. Common tubular secretory mechanisms for organic cations and anions
Common tubular secretory mechanisms for organic cations and anions. Secreted cations are taken up by the tubular epithelium via OCTs, driven by the negative membrane potential and secreted across the apical membrane via antiporters in exchange for protons. Secreted anions are taken up across the basolateral membrane by antiporters in exchange for αKG. They are secreted across the apical membrane by several different transporters including the multidrug resistant protein MDR-2.
Source: Renal Handling of Organic Solutes, Vander's Renal Physiology, 8e
Citation: Eaton DC, Pooler JP. Vander's Renal Physiology, 8e; 2017 Available at: Accessed: October 21, 2017
Copyright © 2017 McGraw-Hill Education. All rights reserved