1. Outcome of LASIK in Pre-Descemet’s Membrane Corneal Dystrophy
Eung Kweon Kim, MD, Ph.D1;
Jung Won Park, MD2; Tae-im Kim, MD, Ph.D1;
Woosuk Chung, MD3; Sekyung Kim, MD 1
1 Corneal Dystrophy Research Institute, Department of Ophthalmology,
Yonsei University College of Medicine, Seoul, Korea
2Daegu Yonsei Eye Clinic, Daegu, Korea
3Siloam Eye Hospital, Seoul, Korea
The authors have no financial interest in the subject matter of this poster.

2. Introduction Pre-Descemet’s membrane corneal dystrophy (PDMCD)
Rare corneal dystrophy
Numerous tiny pleomorphic opacities located in the deep stroma right before the Descemet’s membrane
Several studies have documented adverse outcomes of LASIK in patients with other corneal dystrophies. The safety of LASIK in Pre-Descemet’s membrane corneal dystrophy is unknown.
Roo Min Jun, MD et al. Avellino Corneal Dystrophy after LASIK
Ophthalmology 2004;111:463–468

3. Objective
We report the outcome of LASIK in a patient with pre-Descemet’s membrane corneal dystrophy.

4. Case Outcome measurements
A 28-year-old man visited our clinic for corneal opacities in both eyes.
He (patient 1; Pt1) accompanied with older sister (Pt2).
Pre-Descemet’s membrane opacities were observed both in the patient and his sister.
Patient (Pt1) did not received any operation on his eyes
but his sister (Pt2) underwent LASIK on both eyes 2 years ago.
Outcome measurements
BCVA (best-corrected visual acuity)
Slit-lamp examination
Confocal microscopy (ConfoScan 4; Nidek Technologies, Vigonza, Italy)
Fourier domain-OCT (RTVue-100, Optovue, Inc, Fremont, CA)

5. Result
BCVA
20/20 on both eyes of Pt1 and Pt2
There was no significant difference in visual acuity, clinical feature and confocal microscopic findings between two patients.
A. PDMCD of Pt1
B. PDMCD after LASIK of Pt2
▲ Bilateral numerous small, gray-white faint opacities in posterior corneal stroma in both patients.

6. Slit lamp examination
A. PDMCD of Pt1
B. PDMCD after LASIK of Pt2
The opacities were localized in deep stroma right before the Descemet’s membrane in both patients.
Opacities extends to the limbus in both patients.

7. Slit lamp examination
B. PDMCD after LASIK of Pt2
A. PDMCD of Pt1
▲ The opacities became more evident in scleral scatter.
No difference in severity of the opacities between two patients.

8. FD-OCT
A. PDMCD of Pt1
B. PDMCD after LASIK of Pt2
There were no opacities around LASIK flap wound (B. red arrowheads).

9. Confocal Microscopy
A. PDMCD of Pt1
B. PDMCD after LASIK of Pt2
Numerous polymorphic hyper-reflective, irregular deposits located in posterior stroma.

10. Conclusion
LASIK didn’t cause significant clinical deterioration of pre-Descemet’s membrane corneal dystrophy for 2 years.
Further long term observations of a greater number of patients are required to confirm these findings.