Presentation is loading. Please wait.

Presentation is loading. Please wait.

Overexpression of β-Catenin and Cyclin D1 is Associated with Poor Overall Survival in Patients with Stage IA–IIA Squamous Cell Lung Cancer Irrespective.

Published byLilian Bell Modified over 6 years ago

Similar presentations

Presentation on theme: "Overexpression of β-Catenin and Cyclin D1 is Associated with Poor Overall Survival in Patients with Stage IA–IIA Squamous Cell Lung Cancer Irrespective."— Presentation transcript:

1 Overexpression of β-Catenin and Cyclin D1 is Associated with Poor Overall Survival in Patients with Stage IA–IIA Squamous Cell Lung Cancer Irrespective of Adjuvant Chemotherapy  Yujin Kim, BS, DongHao Jin, MD, PhD, Bo Bin Lee, BS, Eun Yoon Cho, MD, PhD, Joungho Han, MD, PhD, Young Mog Shim, MD, PhD, Hong Kwan Kim, MD, PhD, Duk-Hwan Kim, MD, PhD  Journal of Thoracic Oncology  Volume 11, Issue 12, Pages (December 2016) DOI: /j.jtho Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 Immunohistochemistry of β-catenin and cyclin D1 in NSCLC. (A) Expression levels of β-catenin and cyclin D1 were analyzed using immunohistochemical staining. Representative images of positive staining are shown in adenocarcinoma (upper) and squamous cell carcinoma (lower) (×200). For β-catenin, mainly membrane and cytoplasm was stained and nuclear expression was very rare. Only cytoplasmic staining was judged as positive. Cyclin D1 was stained mainly in nucleus. (B) Prevalence of overexpression of β-catenin and cyclin D1 proteins is shown in adenocarcinoma, squamous cell carcinoma, and other cell types of NSCLC. p Values were based on Pearson’s chi-square test or Fisher’s exact test. Correlation between expression levels of β-catenin and cyclin D1 was analyzed using Spearman’s correlation coefficient in 260 adenocarcinomas (C) and in 272 squamous cell carcinomas (D). “Adenoca” and “Squamous” indicate adenocarcinoma and squamous cell carcinoma, respectively. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 Combined effect of β-catenin and cyclin D1 on overall survival in squamous cell carcinoma. Combined effect of β-catenin and cyclin D1 on overall survival was analyzed using the log rank test in 272 squamous cell carcinomas that were stratified by pathologic stage. Simultaneous overexpression of β-catenin and cyclin D1 was significantly associated with poor overall survival in stage IA (A) and stage IB (B), and tended to reduce the overall survival rate in stage IIA (C), but not in stages IIB (D) and IIIA (E). Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

4 Figure 3 The effect of β-catenin and cyclin D1 on phospho-pRb (Ser-807/811) level and Ki-67 proliferation index in stage IA–IIA squamous cell carcinomas. pRb levels phosphorylated on serine 807/811 residue (A) and Ki-67 proliferation index (B) were compared according to the expression status of β-catenin and cyclin D1. Stage IA–IIA squamous cell carcinoma patients were divided into four groups according to expression status of β-catenin and cyclin D1. Group 1 indicates patients without overexpression of β-catenin and cyclin D1. Groups 2 and 3 represent patients with overexpression of either β-catenin or cyclin D1, respectively. Group 4 consists of patients with overexpression of both β-catenin and cyclin D1. The phosphorylated pRb was stained using polyclonal anti-phospho-pRb (Ser-807/811) antibody (Cell Signaling, Danvers, MA). The phospho-pRb (Ser-807/811) levels and Ki-67 index did not show a significant difference among groups irrespective of adjuvant chemotherapy. p Values were calculated using Kruskal-Wallis test. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

5 Supplementary Figure 1 Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

6 Supplementary Figure 2 Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

7 Supplementary Figure 3 Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Download ppt "Overexpression of β-Catenin and Cyclin D1 is Associated with Poor Overall Survival in Patients with Stage IA–IIA Squamous Cell Lung Cancer Irrespective."

Similar presentations

Lung squamous cell carcinoma

Lung squamous cell carcinoma
Sukki Cho, MD, Kyung-Min Ryu, MD, Yoon-Jin Hwang, MD, Eung Bae Lee, MD 

Sukki Cho, MD, Kyung-Min Ryu, MD, Yoon-Jin Hwang, MD, Eung Bae Lee, MD 
Carcinoma NOS is a Common Histologic Diagnosis and is Increasing in Proportion Among Non-small Cell Lung Cancer Histologies  Sai-Hong Ignatius Ou, MD,

Carcinoma NOS is a Common Histologic Diagnosis and is Increasing in Proportion Among Non-small Cell Lung Cancer Histologies  Sai-Hong Ignatius Ou, MD,
Significance of the Number of Positive Lymph Nodes in Resected Non-small Cell Lung Cancer  Takayuki Fukui, MD, Shoichi Mori, MD, Kohei Yokoi, MD, Tetsuya.

Significance of the Number of Positive Lymph Nodes in Resected Non-small Cell Lung Cancer  Takayuki Fukui, MD, Shoichi Mori, MD, Kohei Yokoi, MD, Tetsuya.
Liver Metastasis Is Associated with Poor Progression-Free Survival in Patients with Non–Small Cell Lung Cancer Treated with Nivolumab  Tomoko Funazo,

Liver Metastasis Is Associated with Poor Progression-Free Survival in Patients with Non–Small Cell Lung Cancer Treated with Nivolumab  Tomoko Funazo,
Who Are Less Likely to Receive Subsequent Chemotherapy Beyond First-Line Therapy for Advanced Non-small Cell Lung Cancer?: Implications for Selection.

Who Are Less Likely to Receive Subsequent Chemotherapy Beyond First-Line Therapy for Advanced Non-small Cell Lung Cancer?: Implications for Selection.
High Expression of PHGDH Predicts Poor Prognosis in Non–Small Cell Lung Cancer  Jinhong Zhu, Jianqun Ma, Xudong Wang, Tianjiao Ma, Shu Zhang, Wei Wang,

High Expression of PHGDH Predicts Poor Prognosis in Non–Small Cell Lung Cancer  Jinhong Zhu, Jianqun Ma, Xudong Wang, Tianjiao Ma, Shu Zhang, Wei Wang,
MET Exon 14 Skipping Mutations in Lung Adenocarcinoma: Clinicopathologic Implications and Prognostic Values  Geun Dong Lee, MD, PhD, Seung Eun Lee, MD,

MET Exon 14 Skipping Mutations in Lung Adenocarcinoma: Clinicopathologic Implications and Prognostic Values  Geun Dong Lee, MD, PhD, Seung Eun Lee, MD,
Who Are Less Likely to Receive Subsequent Chemotherapy Beyond First-Line Therapy for Advanced Non-small Cell Lung Cancer?: Implications for Selection.

Who Are Less Likely to Receive Subsequent Chemotherapy Beyond First-Line Therapy for Advanced Non-small Cell Lung Cancer?: Implications for Selection.
Prognostic Significance of the Number of Lymph Nodes Removed at Lobectomy in Stage IA Non-small Cell Lung Cancer  Sai-Hong Ignatius Ou, MD, PhD, Jason.

Prognostic Significance of the Number of Lymph Nodes Removed at Lobectomy in Stage IA Non-small Cell Lung Cancer  Sai-Hong Ignatius Ou, MD, PhD, Jason.
A Japanese Lung Cancer Registry Study: Prognosis of 13,010 Resected Lung Cancers  Hisao Asamura, MD, Tomoyuki Goya, MD, Yoshihiko Koshiishi, MD, Yasunori.

A Japanese Lung Cancer Registry Study: Prognosis of 13,010 Resected Lung Cancers  Hisao Asamura, MD, Tomoyuki Goya, MD, Yoshihiko Koshiishi, MD, Yasunori.
Prognostic Significance of PD-L1 in Patients with Non–Small Cell Lung Cancer: A Large Cohort Study of Surgically Resected Cases  Jong-Mu Sun, MD, Wei.

Prognostic Significance of PD-L1 in Patients with Non–Small Cell Lung Cancer: A Large Cohort Study of Surgically Resected Cases  Jong-Mu Sun, MD, Wei.
SC17.02 Lung Cancer in China: Challenges and Perspectives

SC17.02 Lung Cancer in China: Challenges and Perspectives
A Novel Classification of MUC1 Expression Is Correlated with Tumor Differentiation and Postoperative Prognosis in Non–Small Cell Lung Cancer  Shinjiro.

A Novel Classification of MUC1 Expression Is Correlated with Tumor Differentiation and Postoperative Prognosis in Non–Small Cell Lung Cancer  Shinjiro.
Prognostic Significance of TAZ Expression in Resected Non-Small Cell Lung Cancer  Mian Xie, MD, PhD, Li Zhang, MD, Chao-Sheng He, MD, Jin-Hui Hou, MD,

Prognostic Significance of TAZ Expression in Resected Non-Small Cell Lung Cancer  Mian Xie, MD, PhD, Li Zhang, MD, Chao-Sheng He, MD, Jin-Hui Hou, MD,
Prognostic Significance of C-Reactive Protein and Smoking in Patients with Advanced Non-small Cell Lung Cancer Treated with First-Line Palliative Chemotherapy 

Prognostic Significance of C-Reactive Protein and Smoking in Patients with Advanced Non-small Cell Lung Cancer Treated with First-Line Palliative Chemotherapy 
Significance of P53 and Rb protein expression in surgically treated non-small cell lung cancers  Yung-Chie Lee, MD, PhD, Yih-Leong Chang, MD, Shi-Ping.

Significance of P53 and Rb protein expression in surgically treated non-small cell lung cancers  Yung-Chie Lee, MD, PhD, Yih-Leong Chang, MD, Shi-Ping.
APLCC ORAL ABSTRACT SESSIONS - MONDAY, NOVEMBER 26

APLCC ORAL ABSTRACT SESSIONS - MONDAY, NOVEMBER 26
Results of Surgical Treatment for Patients with Small Cell Lung Cancer

Results of Surgical Treatment for Patients with Small Cell Lung Cancer
Adjuvant Chemotherapy with 5-Fluorouracil and Cisplatin in Lymph Node-Positive Thoracic Esophageal Squamous Cell Carcinoma  Jeeyun Lee, MD, Kyoung-Eun.

Adjuvant Chemotherapy with 5-Fluorouracil and Cisplatin in Lymph Node-Positive Thoracic Esophageal Squamous Cell Carcinoma  Jeeyun Lee, MD, Kyoung-Eun.

Similar presentations

Ads by Google