Presentation is loading. Please wait.

Presentation is loading. Please wait.

Volume 55, Issue 2, Pages (February 1999)

Similar presentations


Presentation on theme: "Volume 55, Issue 2, Pages (February 1999)"— Presentation transcript:

1 Volume 55, Issue 2, Pages 500-511 (February 1999)
Effects of new analogues of vitamin D on bone cells: Implications for treatment of uremic bone disease  Christopher W. Mcintyre, Neil J. Schroeder, Jacqueline M. Burrin, John Cunningham  Kidney International  Volume 55, Issue 2, Pages (February 1999) DOI: /j x Copyright © 1999 International Society of Nephrology Terms and Conditions

2 Figure 1 Molecular structures of calcitriol, paricalcitol, 22-oxacalcitriol (OCT), and 1,25 (OH)2DHT2. Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

3 Figure 2 Release of interleukin (IL)-6 from MG 63 cells after incubation with the sterols for six hours. *P < 0.05 significance compared with CS-medium control values. N = 36 for each sterol. Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

4 Figure 3 Release of IL-6 from MG 63 cells after incubation with the sterols for 24hours. *P < 0.05 significance compared with CS-medium control values. N = 64 for each sterol. Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

5 Figure 4 Release of IL-6 from SaOS-2 cells after incubation with the sterols for 24hours. P < 0.05 significance compared with CS-medium control values. N = 32 for each sterol. Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

6 Figure 5 Dose response curve for IL-6 release from MG 63 cells in response to 24-hour incubation with exogenous IL-1β. Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

7 Figure 6 Effect of the amount of cDNA used per PCR reaction on the optical density of the final product. Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

8 Figure 7 Effect of the vitamin D sterols on IL-6 mRNA levels in MG 63 cells after six hours. *Indicates statistically significant difference between sterol-treated mRNA level and control mRNA level (P < 0.05, N = 3). Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

9 Figure 8 Effect of the vitamin D sterols on IL-6 mRNA levels in MG 63 cells after 24hours. *Indicates statistically significant difference between sterol-treated mRNA level and control mRNA level (P < 0.05, N = 3). Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

10 Figure 9 Effect of the vitamin D sterols on IL-6 mRNA levels in SaOS-2 cells after 24hours. *Indicates statistically significant difference between sterol-treated mRNA level and control mRNA level (P < 0.05, N = 3). Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions


Download ppt "Volume 55, Issue 2, Pages (February 1999)"

Similar presentations


Ads by Google