1. Differential effects of vitamin D receptor activators on vascular calcification in uremic rats 
M. Mizobuchi, J.L. Finch, D.R. Martin, E. Slatopolsky 
Kidney International 
Volume 72, Issue 6, Pages (September 2007)
DOI: /sj.ki
Copyright © 2007 International Society of Nephrology Terms and Conditions

2. Figure 1
Aortic Ca content in normal rats and 5/6 nephrectomized uremic rats treated with vehicle (UC), 0.04 μg/kg of calcitriol (1,25D3), 0.16 μg/kg of doxercalciferol (1αD2), or paricalcitol (19-nor). Each drug was given intraperitoneally three times a week for 1 month. Values are mean±s.e.m. (n=6 or 7). P< by analysis of variance. **P<0.01 versus UC; ##P<0.01 versus 19-nor by post hoc, Scheffe test.
Kidney International  , DOI: ( /sj.ki )
Copyright © 2007 International Society of Nephrology Terms and Conditions

3. Figure 2
Representative microphotograph of von Kossa staining of aorta from uremic rats treated with vehicle (UC), 0.04 μg/kg of calcitriol (1,25D3), 0.16 μg/kg of doxercalciferol (1αD2), or paricalcitol (19-nor). Each drug was given intraperitoneally three times a week for 1 month. Original magnification at × 400.
Kidney International  , DOI: ( /sj.ki )
Copyright © 2007 International Society of Nephrology Terms and Conditions

4. Figure 3
Effects of 0.10 μg/kg of doxercalciferol (1αD2) or 0.24 μg/kg of paricalcitol (19-nor) on serum levels of (a) ionized Ca, (b) total Ca, (c) P, and (d) Ca × P product in uremic rats. Each drug was given intraperitoneally three times a week for 1 month. Values are mean±s.e.m. (n=6). #P<0.05 versus 19-nor by non-paired t-test.
Kidney International  , DOI: ( /sj.ki )
Copyright © 2007 International Society of Nephrology Terms and Conditions

5. Figure 4
Effects of 0.10 μg/kg of doxercalciferol (1αD2) or 0.24 μg/kg of paricalcitol (19-nor) on aortic Ca content in uremic rats. Each drug was given intraperitoneally three times a week for 1 month. Values are mean±s.e.m. (n=6). ##P<0.01 versus 19-nor by non-paired t-test.
Kidney International  , DOI: ( /sj.ki )
Copyright © 2007 International Society of Nephrology Terms and Conditions

6. Figure 5
Effects of 0.04 μg/kg of calcitriol (1,25D3), 0.10 μg/kg of doxercalciferol (1αD2), or 0.16 μg/kg of paricalcitol (19-nor) on Runx2 mRNA expression levels in aorta from uremic rats. Runx2 mRNA levels were analyzed by real-time RT-PCR technique. Each drug was given intraperitoneally three times a week for 1 month. Values are mean±s.e.m. (n=6). P<0.01 by analysis of variance. *P<0.05 versus UC; ••P<0.01 and •P<0.05 versus 19-nor by post hoc, Scheffe test.
Kidney International  , DOI: ( /sj.ki )
Copyright © 2007 International Society of Nephrology Terms and Conditions

7. Figure 6
Effects of 0.04 μg/kg of calcitriol (1,25D3), 0.10 μg/kg of doxercalciferol (1αD2), or 0.16 μg/kg of paricalcitol (19-nor) on mRNA expression levels in aorta from uremic rats. Osteocalcin mRNA levels were analyzed by real-time RT-PCR technique. Each drug was given intraperitoneally three times a week for 1 month. Values are mean±s.e.m. (n=6). P<0.01 by analysis of variance. **P<0.01 and *P<0.05 versus UC; ••P<0.01 and •P<0.05 versus 19-nor by post hoc, Scheffe test.
Kidney International  , DOI: ( /sj.ki )
Copyright © 2007 International Society of Nephrology Terms and Conditions

8. Figure 7
Representative microphotograph of immunohistochemistry for Runx2 or osteocalcin in aorta from uremic rats treated with 0.10 μg/kg of doxercalciferol (1αD2) or 0.16 μg/kg of paricalcitol (19-nor). Each drug was given intraperitoneally three times a week for 1 month. Original magnification at (a) × 100 and (b) × 200.
Kidney International  , DOI: ( /sj.ki )
Copyright © 2007 International Society of Nephrology Terms and Conditions