1. DNA Methylation Regulates Gene Expression in Intracranial Aneurysms
Lanbing Yu, Jia Wang, Shuo Wang, Dong Zhang, Yuanli Zhao, Rong Wang, Jizong Zhao 
World Neurosurgery 
Volume 105, Pages (September 2017)
DOI: /j.wneu
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2. Figure 1
Gene methylation distribution. (A) Percentage of equally or differentially methylated CpG sites. (B) Percentages of hypermethylated and hypomethylated CpG sites. (C) Hypermethylated annotation of differentially methylated CpG sites. (D) Hypomethylated annotation of differentially methylated CpG sites.
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3. Figure 2
(A) Cluster analysis of the differentially methylated sites in the gene promoter region, comparing the results from the intracranial aneurysm and superficial temporal artery tissues in the same individual. Red indicates hypermethylation in the aneurysm versus control tissues; blue indicates hypomethylation in the aneurysm. (B) Gene Ontology analysis and Kyoto Encyclopedia of Genes and Genomes analysis.
World Neurosurgery  , 28-36DOI: ( /j.wneu )
Copyright © 2017 Elsevier Inc. Terms and Conditions

4. Figure 2
(A) Cluster analysis of the differentially methylated sites in the gene promoter region, comparing the results from the intracranial aneurysm and superficial temporal artery tissues in the same individual. Red indicates hypermethylation in the aneurysm versus control tissues; blue indicates hypomethylation in the aneurysm. (B) Gene Ontology analysis and Kyoto Encyclopedia of Genes and Genomes analysis.
World Neurosurgery  , 28-36DOI: ( /j.wneu )
Copyright © 2017 Elsevier Inc. Terms and Conditions

5. Figure 3
(A) Cluster analysis of gene expression between the aneurysm and control samples. Individual genes are indicated in each row, and different samples are shown in the columns. Data are expressed as mean and normalized as the difference within groups. Red indicates an up-regulated gene, and green indicates a down-regulated gene. Genes in one cluster may have similar biological functions. (B) Gene Ontology analysis and Kyoto Encyclopedia of Genes and Genomes analysis.
World Neurosurgery  , 28-36DOI: ( /j.wneu )
Copyright © 2017 Elsevier Inc. Terms and Conditions

6. Figure 3
(A) Cluster analysis of gene expression between the aneurysm and control samples. Individual genes are indicated in each row, and different samples are shown in the columns. Data are expressed as mean and normalized as the difference within groups. Red indicates an up-regulated gene, and green indicates a down-regulated gene. Genes in one cluster may have similar biological functions. (B) Gene Ontology analysis and Kyoto Encyclopedia of Genes and Genomes analysis.
World Neurosurgery  , 28-36DOI: ( /j.wneu )
Copyright © 2017 Elsevier Inc. Terms and Conditions

7. Figure 4
Conjoint analysis of differentiated methylation (methylation sites in the promoter regions of genes) and genes with differentiated expression.
World Neurosurgery  , 28-36DOI: ( /j.wneu )
Copyright © 2017 Elsevier Inc. Terms and Conditions

8. Figure 5
Network diagram of gene interaction, plotted based on the interaction of the proteins encoded by their corresponding genes. The red highlighted spots represent the methylation modifications in the promoter regions that are negatively correlated with expression of the downstream genes.
World Neurosurgery  , 28-36DOI: ( /j.wneu )
Copyright © 2017 Elsevier Inc. Terms and Conditions