1. Gene-Based Personalized Nutrition February 2, 2016
DIGITAL NUTRITION, LLC
Gene-Based Personalized Nutrition
February 2, 2016
Contact: Dr. Fredric D. Abramson
(301) [cell]

2. Confusion! Skepticism! Frustration
The Problem
Confusion! Skepticism! Frustration

3. Consumer Basic Needs Personalized Nutrition Meets These
What can I do to be more fit?
What do I need right now?
What are the best choices for my children?
How can I do even better?
Personalized Nutrition Meets These

4. Consumer Challenge Optimize lifestyle outcomes
Weight loss: What works for one person fails for others
Performance: no single nutrition program delivers maximum performance for everyone
Supplements: Thousands of products; which is best for you

5. Solution Science-Based Personalized Nutrition
Technology delivers real-time science-based data
Proven science shows DNA impact on metabolism
Genetic set-points differ from person to person
Baseline requirements depends on person’s DNA
Relates to metabolic rates
Dietary inputs and lifestyle important
Adjust nutrient calibration based on person’s dietary patterns
Mobile scanning inputs nutrient data
Weight Watchers “Point” app
Imagine Google Maps for Personalized Nutrition

6. Gene-Nutrient Interaction Examples
Vitamin B6 ALPL SNP rs
T/T genotype has normal B6 levels
C/T and C/C genotypes have lower B6 levels
Vitamin C SVCT1 SNP rs
A/A genotypes have higher C levels
Magnesium CNNM2 SNP rs
G/G genotypes have higher magnesium levels

7. Gene-Nutrient Interaction Examples
Folate MTHFR SNP rs
T/T genotypes have lower enzymatic activity
Therefore, require more folate intake than C/C or C/T types
Iron HFE SNP rs884409
Hemochromatosis in homozygotes for minor allele
Heterozygous have high normal iron levels
Heterozygous athletes with iron supplementation
Can compromise performance by over-elevating iron levels
Sugar Glut2 SNP rs5400
Homozygous TT monthly consume 1.1 – 1.9 pounds more sugar than CC, CT types

8. Gene-Nutrient Interaction Examples
Vitamin B12 FUT2
SNP rs
High levels for CC genotype
Average levels for CT genotype
Low levels for TT genotypes
SNP rs492602
Higher levels for the GG genotype
SNP res shows lower levels for GG vegetarians
DIETARY FAT APOA5 SNP rs662799
Homozygous TT – high fat diet  significantly more weight gain than for CT or CC

9. U.S. PATENT System and method for evaluating and providing nutrigenomic data, information and advice
Issued to Fredric Abramson January 25, 2011
Filed January 8, 2002
Expires 2025
Wireless communication method to minimize individual predisposition for developing a disease
Relates individual lifestyle choice data to genetic risk of developing a disease to reduce the risk of developing the disease, and
Communicates lifestyle-disease analysis results to individual

10. Just when I knew all of life’s answers,
UMd2
5/26/2018
Just when I knew all of life’s answers,
They changed all the questions!!
Draft March

11. Examples of personal behavior changes
65 year old overweight female
Belief: wired to eat more sugar
DNA test negative for sugar craving (GLUT2) rs5400
Remembers her parents didn’t let her eat sweets
Changes perspective
48 year old overweight male
Diets not working, including Atkins
DNA test positive for APOA5 obesity & high-fat diet
Obesity linear increases as dietary fat exceeds 30%
Shifts focus to fat content in foods, reads labels

12. Market Segment Attributes
Multi-vitamin and supplement purchasers
170 Million U.S. vitamin consumers
$23 Billion U.S. market
$84.3 Billion World-Wide
5%+ annual growth rate
Physical Performance
52.9 Million U.S. health club members
General health and wellness concerns
Weight, fitness, fatigue, anti-aging, heart health, bone health

13. Mobile & DNA = Connectivity
Mobile environment 1
58% of American adults have a smartphone
83% % % % 65+
81% with $75,000 household income
71% college graduates
50% download apps
Mobile Health
30 million wearable devices shipped 2012
75 million US adults used mobile in 2013 to access health information
385 million Apple Watch sales expected 2018
1 Source: Pew Research Center 2014 (
DIGITAL NUTRITION, LLC INVESTOR SLIDE DECK

14. IT’S TIME TO CREATE THE FUTURE
“The flying machine which will really fly might be evolved by the combined and continuous efforts of mathematicians and mechanicians in from one million to ten million years.”
9 October 1903
“We started assembly today.”
Orville Wright’s Diary
9 October 1903

15. Thank you
Fredric D. Abramson, Ph.D., S.M., Esq.
(301)