1. Does statin therapy reduce plasma VEGF levels in humans
Does statin therapy reduce plasma VEGF levels in humans? A systematic review and meta-analysis of randomized controlled trials 
Amirhossein Sahebkar, Maria Chantal Ponziani, Ilaria Goitre, Simona Bo 
Metabolism - Clinical and Experimental 
Volume 64, Issue 11, Pages (November 2015)
DOI: /j.metabol
Copyright © 2015 Elsevier Inc. Terms and Conditions

2. Fig. 1
Flow chart of the number of studies identified and included into the meta-analysis.
Metabolism - Clinical and Experimental  , DOI: ( /j.metabol )
Copyright © 2015 Elsevier Inc. Terms and Conditions

3. Fig. 2
Forest plot displaying weighted mean difference and 95% confidence intervals for the impact of statin therapy on plasma VEGF concentrations. Lower plot shows leave-one-out sensitivity analysis.
Metabolism - Clinical and Experimental  , DOI: ( /j.metabol )
Copyright © 2015 Elsevier Inc. Terms and Conditions

4. Fig. 3
Meta-regression plots of the association between mean changes in plasma VEGF concentrations with duration of statin therapy, magnitude of LDL-C reduction, and molar dose of statins.
Metabolism - Clinical and Experimental  , DOI: ( /j.metabol )
Copyright © 2015 Elsevier Inc. Terms and Conditions

5. Fig. 4
Funnel plot displaying publication bias in the studies reporting the impact of statin therapy on plasma VEGF concentrations. Open diamond represents observed effect size; closed diamond represents imputed effect size.
Metabolism - Clinical and Experimental  , DOI: ( /j.metabol )
Copyright © 2015 Elsevier Inc. Terms and Conditions

6. Fig. 1S
Forest plot displaying weighted mean difference and 95% confidence intervals for the impact of statin therapy on plasma VEGF concentrations in trials with treatment durations of <4weeks (upper plot) and ≥4weeks (lower plot).
Metabolism - Clinical and Experimental  , DOI: ( /j.metabol )
Copyright © 2015 Elsevier Inc. Terms and Conditions

7. Fig. 2S
Forest plot displaying weighted mean difference and 95% confidence intervals for the impact of statin therapy on plasma VEGF concentrations in trials with LDL-cholesterol reductions <50mg/dL (upper plot) and ≥50mg/dL (lower plot).
Metabolism - Clinical and Experimental  , DOI: ( /j.metabol )
Copyright © 2015 Elsevier Inc. Terms and Conditions

8. Fig. 3S
Forest plot displaying weighted mean difference and 95% confidence intervals for the impact of statin therapy on plasma VEGF concentrations in trials with lipophilic (upper plot) and hydrophilic statins (lower plot).
Metabolism - Clinical and Experimental  , DOI: ( /j.metabol )
Copyright © 2015 Elsevier Inc. Terms and Conditions

9. Fig. 4S
Forest plot displaying weighted mean difference and 95% confidence intervals for the impact of statin therapy on plasma VEGF concentrations in trials with diseased (upper plot) and healthy populations (lower plot).
Metabolism - Clinical and Experimental  , DOI: ( /j.metabol )
Copyright © 2015 Elsevier Inc. Terms and Conditions