1. Stem Cell doubling is logarithmic
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Stem Cell doubling is logarithmic

2. Adult versus Umbilical Cord Blood Stem Cells
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Adult versus Umbilical Cord Blood Stem Cells

3. Stem Cell doubling times
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Stem Cell doubling times
Hong-Xing Chang, MD et al. Age related Biological Characterization of Mesenchymal Progenitor Cells in Human Cartilage. Orthopedics | August 2011 – Volume 34 . Issue B: e382 – e 388
Doubling time (h, X±S)
Starting with a single cell, cultured over 30 days….

4. Effects of Aging on Stem Cells
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Effects of Aging on Stem Cells
Indices of aging including oxidative damage, ROS levels and p21 and p53 all increased suggesting a loss of stem cell fitness with age.
hMSC numbers obtained by marrow aspiration decline with age.
There is an age-related decline in overall stem cell “fitness” which might lead to problems when using autologous aged MSC for cell based therapies.

5. Umbilical Cord Blood Safety
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Umbilical Cord Blood Safety
JYT transplants
Lancet 2003
J Am Coll Surg 2005
Thousands of transplants at JYT – no single case of GVHD
413 units of cord blood given, no adverse effects
128 patients given cord blood – no adverse effects

6. HUCB Stem Cells – USFDA Approved Uses (2014)
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HUCB Stem Cells – USFDA Approved Uses (2014)
fda.gov/2014Updates
Cord blood is approved only for use in “hematopoietic stem cell transplantation” procedures, which are done in patients with disorders affecting the hematopoietic (blood forming) system. Cord blood contains blood-forming stem cells that can be used in the treatment of patients with blood cancers such as leukemias and lymphomas, as well as certain disorders of the blood and immune systems.
“Cord blood is useful because it is a source of stem cells that form into blood cells. Cord blood can be used for transplantation in people who need regeneration, that is, ‘regrowth,’ of these blood-forming cells,” - Wonnacott

7. How Umbilical Cord Blood MSCs work
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How Umbilical Cord Blood MSCs work

8. Upgrade to HUCB Stem Cell Extraction Technology
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Upgrade to HUCB Stem Cell Extraction Technology
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