1. ENIGMA OCD working group
Teleconference
April 28th, 2016
1 PM GMT (Greenwich Mean Time)
Amsterdam/Barcelona/Berlin/Milan/Munich/Rome/Zurich 3 PM
Oxford 2 PM
Sao Paulo 10 AM
Tokyo/Kyoto/Seoul 10 PM
Cape Town 3 PM
Los Angeles 6 AM
New York/Toronto/Michigan/Boston 9 AM
Bangalore 6.30 PM

2. Agenda New ENIGMA OCD collaborators Subcortical Manuscript
Status Cortical meTa analysis
Planning Cortical meTa analysis
DTI meTa analysis
Structural Covariance
Status papers side projects (lateralization/lifespan)
Future plans
Cerebellum (Dan Stein)
Sulci analysis (Neda Jahanshad)
Future meetings

3. Agenda New ENIGMA OCD collaborators Subcortical Manuscript
Status Cortical meTa analysis
Planning Cortical meTa analysis
DTI meTa analysis
Structural Covariance
Status papers side projects (lateralization/lifespan)
Future plans
Cerebellum (Dan Stein)
Sulci analysis (Neda Jahanshad)
Future meetings

4. Erika Nurmi, M.D., Ph.D. Assistant Professor-in-Residence
University of California, Los Angeles, USA
Semel Institute for Neuroscience
Paediatric & Adult OCD data
John Piacentini
Sally Ghali
Joseph O’Neill

5. Anthony James, M.D., Ph.D. Adolescent psychiatrist
Oxford University, Oxford, UK
Department of Psychiatry
Adolescent OCD data
Mojtaba Zarei

6. Agenda New ENIGMA OCD collaborators Subcortical Manuscript
Status Cortical meTa analysis
Planning Cortical meTa analysis
DTI meTa analysis
Structural Covariance
Status papers side projects (lateralization/lifespan)
Future plans
Cerebellum (Dan Stein)
Sulci analysis (Neda Jahanshad)
Future meetings

7. Subcortical Manuscript
‘awaiting decision approval’ AJP

8. Agenda New ENIGMA OCD collaborators Subcortical Manuscript
Status Cortical meTa analysis
Planning Cortical meTa analysis
DTI meTa analysis
Structural Covariance
Status papers side projects (lateralization/lifespan)
Future plans
Cerebellum (Dan Stein)
Sulci analysis (Neda Jahanshad)
Future meetings

9. Cortical analyses QC, histograms & statistical analyses
Arnold
Soreni
Finished:
Benedetti
Huyser
Koch
Kwon
Lazaro
Mataix-Cols
Menchon
Nakamae
Nakao
Nurmi
Reddy
Simpson
Spalletta
Stein
Tolin
Walitza
Wang
Beucke
Cheng
Denys
Fitzgerald
Gruner
van den Heuvel
Hoexter

10. Agenda New ENIGMA OCD collaborators Subcortical Manuscript
Status Cortical meTa analysis
Planning Cortical meTa analysis
DTI meTa analysis
Structural Covariance
Status papers side projects (lateralization/lifespan)
Future plans
Cerebellum (Dan Stein)
Sulci analysis (Neda Jahanshad)
Future meetings

11. Planning Cortical meTa analysis
Adult meta-analysis
work in progress (currently running meta-analyses)
Paediatric meta-analysis
Awaiting for Soreni & Arnold output
Meta-analyses will be ran a.s.a.p.

12. Agenda New ENIGMA OCD collaborators Subcortical Manuscript
Status Cortical meTa analysis
Planning Cortical meTa analysis
DTI meTa analysis
Structural Covariance
Status papers side projects (lateralization/lifespan)
Future plans
Cerebellum (Dan Stein)
Sulci analysis (Neda Jahanshad)
Future meetings

13. DOMAIN – OCD DTI meta-analysis
Status (in progress):
Site PI
Preprocessing
Preprocessing QC
Processing
Processing QC
ROI extraction
Amsterdam
Odile van den Heuvel ✔
Cape Town
Dan Stein
Barcelona
Jose Menchon
Seoul
Jun Soo Kwon
Shangai
Zhen Wang
Kyoto
Takashi Nakamae
Munich
Kathrin Koch
Kunming
Yuqi Cheng
Fukuoka
Tomohiro Nakao
Bangalore
Reddy Janardhan
Milan
Francesco Benedetti
Rome
Gianfranco Spalletta
Berlin
Jan-Carl Beucke
New York
Blair Simpson
Zurich
Susanne Walitza
Sao Paulo
Marcelo Batistuzzo
Centrally processed data (Rome)

14. DOMAIN – OCD DTI meta-analysis
Critical aspects:
Image quality varies (a lot) across sites
Clinical data not available for all sites
Deadlines:
All data have to be processed by May 15th
First results by June 1st

15. Agenda New ENIGMA OCD collaborators Subcortical Manuscript
Status Cortical meTa analysis
Planning Cortical meTa analysis
DTI meTa analysis
Structural Covariance
Status papers side projects (lateralization/lifespan)
Future plans
Cerebellum (Dan Stein)
Sulci analysis (Neda Jahanshad)
Future meetings

16. ENIGMA-OCD: Structural Covariance
A secondary meta-analytic approach, lead by Kwon et al. (South Korea) on behalf of ENIGMA-OCD
Pipeline (all conducted by Kwon et al. in South Korea)
Gathering of .csv files (secondary byproducts generated during the procedures of primary subcortical; cortical analyses [lead by van den Heuvel et al.]) sent from van den Heuvel et al. on behalf of ENIGMA-OCD consortium
Calculation of individualized structural covariance matrices (Yun et al., 2015; Yun et al., 2016) using cortical surface area, cortical thickness, and subcortical volumes
Graph theory analyses and network-based statistics for 2) per participant
Statistical analyses (including exploration of intergroup differences as well as relationship with demographic/clinical variables provided) per dataset (from each study sites)
Meta-analytic integration for 3) and 4)

17. ENIGMA-OCD: Structural Covariance
Progression till 2016/APR/26 (all conducted by Kwon et al. in South Korea)
Completion for 1) & 2); ongoing for 3)
Benedetti et al.
Simpsom et al.
Mataix-Cols et al.
Cheng et al.
Spalletta et al.
Menchon et al.
Denys et al.
Stein et al.
Fitzgerald et al.
Heuvel et al.
Tolin et al.
Gruner et al.
Koch et al.
Walitza et al.
Huyser et al.
Kwon et al.
Wang et al.
Lazaro et al.
Nakamae et al.
Beucke et al.
Nurmi et al.
Nakao et al.
Hoexter et al.

18. ENIGMA-OCD: Structural Covariance
Progression till 2016/APR/26 (all conducted by Kwon et al. in South Korea)
Ongoing for 1)
Reddy et al.
Matching cortical + subcortical data per participant (ongoing)
Beucke et al.
Waiting for the .csv files to be received
Arnold et al.
Soreni et al.

19. ENIGMA-OCD: Structural Covariance
A secondary meta-analytic approach, lead by Kwon et al. (South Korea) on behalf of ENIGMA-OCD
Pipeline (all conducted by Kwon et al. in South Korea)
Gathering of .csv files (secondary byproducts generated during the procedures of primary subcortical; cortical analyses [lead by van den Heuvel et al.]) sent from van den Heuvel et al. on behalf of ENIGMA-OCD consortium
Calculation of individualized structural covariance matrices (Yun et al., 2015; Yun et al., 2016) using cortical surface area, cortical thickness, and subcortical volumes
Graph theory analyses and network-based statistics for 2) per participant
Statistical analyses (including exploration of intergroup differences as well as relationship with demographic/clinical variables provided) per dataset (from each study sites)
Meta-analytic integration for 3) and 4)

20. ENIGMA-OCD: Structural Covariance
Progression till 2016/APR/26 (all conducted by Kwon et al. in South Korea)
Completion for 1) & 2); ongoing for 3)
Benedetti et al.
Huyser et al.
Nurmi et al.
Beucke et al.
Koch et al.
Simpsom et al.
Cheng et al.
Kwon et al.
Spalletta et al.
Denys et al.
Lazaro et al.
Stein et al.
Fitzgerald et al.
Mataix-Cols et al.
Tolin et al.
Gruner et al.
Menchon et al.
Walitza et al.
Heuvel et al.
Nakamae et al.
Wang et al.
Hoexter et al.
Nakao et al.

21. ENIGMA-OCD: Structural Covariance
Progression till 2016/APR/26 (all conducted by Kwon et al. in South Korea)
Ongoing for 1)
Reddy et al.
Matching cortical + subcortical data per participant (ongoing)
Beucke et al.
Arnold et al.
Waiting for the .csv files to be received
Soreni et al.

22. Agenda New ENIGMA OCD collaborators Subcortical Manuscript
Status Cortical meTa analysis
Planning Cortical meTa analysis
DTI meTa analysis
Structural Covariance
Status papers side projects (lateralization/lifespan)
Future plans
Cerebellum (Dan Stein)
Sulci analysis (Neda Jahanshad)
Future meetings

23. Status papers side projects
ENIGMA LifeSpan
Subcortical paper: under review at Human Brain Mapping
Cortical paper: analyses ongoing
ENIGMA Lateralization
Subcortical paper: under review at Brain Imaging and Behaviour

24. Agenda New ENIGMA OCD collaborators Subcortical Manuscript
Status Cortical meTa analysis
Planning Cortical meTa analysis
DTI meTa analysis
Structural Covariance
Status papers side projects (lateralization/lifespan)
Future plans
Cerebellum (Dan Stein)
Sulci analysis (Neda Jahanshad)
Future meetings

25. Agenda New ENIGMA OCD collaborators Subcortical Manuscript
Status Cortical meTa analysis
Planning Cortical meTa analysis
DTI meTa analysis
Structural Covariance
Status papers side projects (lateralization/lifespan)
Future plans
Cerebellum (Dan Stein)
Sulci analysis (Neda Jahanshad)
Future meetings

26. Agenda New ENIGMA OCD collaborators Subcortical Manuscript
Status Cortical meTa analysis
Planning Cortical meTa analysis
DTI meTa analysis
Structural Covariance
Status papers side projects (lateralization/lifespan)
Future plans
Cerebellum (Dan Stein)
Sulci analysis (Neda Jahanshad)
Future meetings

27. Future meetings ENIGMA-PI meeting June 23-24, 2016
Options to meet (please let us know if you plan to go!)
Odile’s mobile phone: (send me whatsapp if you would like to meet adhoc)
SOBP, Atlanta, Georgia, USA, May 12-14, 2016
Saturday May 14 ( PM), ENIGMA symposium (Odile will present OCD subcortical meta-mega-analysis results)
Friday May 13 (5.30-9PM) ENIGMA blitz session
OHBM, Geneva, Switzerland, June 22-29, 2016
Saturday June 25, Premika/Odile will meet with Ye-Yeon – other people around as well?
Next ENIGMA-OCD teleconference
Monday June 13 or July 11 (same time)?