1. Volume 144, Issue 4, Pages 1269-1275 (October 2013)
Improving Clinical Interpretation of the Anti-Platelet Factor 4/Heparin Enzyme-Linked Immunosorbent Assay for the Diagnosis of Heparin-Induced Thrombocytopenia Through the Use of Receiver Operating Characteristic Analysis, Stratum-Specific Likelihood Ratios, and Bayes Theorem 
Robert A. Raschke, MD, Steven C. Curry, MD, Theodore E. Warkentin, MD, Richard D. Gerkin, MD 
CHEST 
Volume 144, Issue 4, Pages (October 2013)
DOI: /chest
Copyright © 2013 The American College of Chest Physicians Terms and Conditions

2. Figure 1
AUROCs and 95% CIs for three interpretation approaches. A, Currently recommended single cutoff of 0.4 optical density (OD). B, Single cutoff of 0.8 OD. C, Stratified interpretation. All statistics in this figure were derived from IgG-specific anti-platelet factor 4/heparin enzyme-linked immunosorbent assay results (n = 1,958). The AUROC is a measure of the ability of the test to discriminate between patients with and without disease. Note that the highest polygonal AUROC (best discriminant accuracy) is achieved in the stratified model (C) and that it is statistically significantly superior to a cutoff 0.4 OD (A), since the 95% CIs do not overlap. AUROC = area under the receiver operating characteristic curve.
CHEST  , DOI: ( /chest )
Copyright © 2013 The American College of Chest Physicians Terms and Conditions