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Randomized Controlled Trial of Osmotic-Release Methylphenidate With Cognitive- Behavioral Therapy in Adolescents With Attention-Deficit/Hyperactivity Disorder.

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Presentation on theme: "Randomized Controlled Trial of Osmotic-Release Methylphenidate With Cognitive- Behavioral Therapy in Adolescents With Attention-Deficit/Hyperactivity Disorder."— Presentation transcript:

1 Randomized Controlled Trial of Osmotic-Release Methylphenidate With Cognitive- Behavioral Therapy in Adolescents With Attention-Deficit/Hyperactivity Disorder and Substance Use Disorders  Paula D. Riggs, M.D., Theresa Winhusen, Ph.D., Robert D. Davies, M.D., Jeffrey D. Leimberger, Ph.D., Susan Mikulich-Gilbertson, Ph.D., Constance Klein, L.C.S.W., Marilyn Macdonald, B.A., Michelle Lohman, R.N., Genie L. Bailey, M.D., Louise Haynes, M.S.W., William B. Jaffee, Ph.D., Nancy Haminton, MPA, Candace Hodgkins, Ph.D., Elizabeth Whitmore, Ph.D., Kathlene Trello-Rishel, M.D., Leanne Tamm, Ph.D., Michelle C. Acosta, Ph.D., Charlotte Royer-Malvestuto, M.Ed., Geetha Subramaniam, M.D., Marc Fishman, M.D., Beverly W. Holmes, M.S.W., Mary Elyse Kaye, B.S.N., Mark A. Vargo, Ph.D., George E. Woody, M.D., Edward V. Nunes, M.D., David Liu, M.D.  Journal of the American Academy of Child & Adolescent Psychiatry  Volume 50, Issue 9, Pages (September 2011) DOI: /j.jaac Copyright © 2011 American Academy of Child and Adolescent Psychiatry Terms and Conditions

2 FIGURE 1 Study flow diagram. Note: CBT = cognitive-behavioral therapy; OROS = osmotic-release methylphenidate. Journal of the American Academy of Child & Adolescent Psychiatry  , DOI: ( /j.jaac ) Copyright © 2011 American Academy of Child and Adolescent Psychiatry Terms and Conditions

3 FIGURE 2 Change in DSM-IV Attention-Deficit/Hyperactivity Disorder Rating Scale (ADHD-RS) scores by treatment group. Note: Estimates are derived from the cubic longitudinal model with random subject and linear time effects and serially correlated residual errors. OROS = osmotic-release methylphenidate. Journal of the American Academy of Child & Adolescent Psychiatry  , DOI: ( /j.jaac ) Copyright © 2011 American Academy of Child and Adolescent Psychiatry Terms and Conditions

4 FIGURE 3 Change in past 28-day non-tobacco drug use by treatment group. Note: Past 28-day drug use trajectories were modeled based on the assumption of normal distribution for the response variable (intent-to-treat sample; here, N = 302, one subject did not have valid data for this variable). Estimates were derived from the selected quadratic longitudinal model with random subject and linear time effects. OROS = osmotic-release methylphenidate. Journal of the American Academy of Child & Adolescent Psychiatry  , DOI: ( /j.jaac ) Copyright © 2011 American Academy of Child and Adolescent Psychiatry Terms and Conditions

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