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Volume 132, Issue 4, Pages (October 2013)

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Presentation on theme: "Volume 132, Issue 4, Pages (October 2013)"— Presentation transcript:

1 Volume 132, Issue 4, Pages 444-449 (October 2013)
PON1 Q192R genotype influences clopidogrel responsiveness by relative platelet inhibition instead of on-treatment platelet reactivity  Xiaoqi Li, Lanning Zhang, Xi Chen, Fei Qu, Jiayue Li, Cong Ma, Jie Yang, Bin Xu, Hongjuan Wang, Qiang Xu, Yuxiao Zhang, Yang Li, Caiyi Lu, Tong Yin  Thrombosis Research  Volume 132, Issue 4, Pages (October 2013) DOI: /j.thromres Copyright © 2013 Elsevier Ltd Terms and Conditions

2 Fig. 1 Influence of PON1 and CYP2C19 genotypes on the relative inhibition of ADP-induced platelet aggregation a. PON1 Q192R genotype and relative inhibition of platelet aggregation. b. CYP2C19*2 genotype and relative inhibition of platelet aggregation. Box-plot analyses show the relative inhibition of 20umol/L ADP-induced platelet aggregation (%) from pretreatment to post-treatment of clopidogrel 5-day maintenance dose in relation to genotypes. Boxes indicate 25th and 75th percentiles and whiskers denote 10th and 90th percentiles. ADP denotes adenosine diphosphate. Thrombosis Research  , DOI: ( /j.thromres ) Copyright © 2013 Elsevier Ltd Terms and Conditions

3 Fig. 2 Influence of PON1 and CYP2C19 genotypes on ADP induced on-treatment platelet aggregation a. PON1 Q192R genotype and on-treatment platelet aggregation. b. CYP2C19*2 genotype and on-treatment platelet aggregation. Box-plot analyses show the ADP-induced platelet aggregation (%) in relation to genotypes. Boxes indicate 25th and 75th percentiles and whiskers denote 10th and 90th percentiles. ADP denotes adenosine diphosphate. Thrombosis Research  , DOI: ( /j.thromres ) Copyright © 2013 Elsevier Ltd Terms and Conditions


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