3. Translational Research

4. Why should you care about translational research?
The public cares. Translation into therapies justifies spending on science.
Medical schools care. Discoveries from translation can drive clinical revenue, makes a hospital “cutting edge.”
Clinicians care. This is why many physicians choose to work at academic medical centers.
Increasing impatience to improve the health of the public.
Care about the health of your community.

5. So where is the tension? Inadequate NIH financial support
Progressive decline in the number of physician- scientists
Pressure on clinicians to produce clinical income
Increased competition to secure post-doc position
Pressure on basic scientists to follow a traditional route to secure funding

6. Remember these guys?
Brown and Goldstein, to be exact.

8. What can YOU do?
Learn to define a health problem with as much precision as you do a basic science hypothesis
Promote discussion and collaboration among basic scientists, clinical researchers, and clinicians to generate new ideas
Develop or learn new methods, which can lead to new projects, fresh directions
Take responsibility to define your career

9. Translational Research Competencies
Identify major clinical or public health problems and relevant research questions.
Literature critique: Identify, interpret, and critique the state of knowledge regarding a question.
Design and write a protocol for clinical and translational research.
Research implementation: Identify appropriate study design as to feasibility, efficiency, and bias-free inference.
Sources of error: Evaluate reliability, validity and quality assurance.

10. Core Competencies, continued
Use appropriate sample size, power.
Apply basic statistical principles.
Employ effective information management.
Identify, evaluate, and minimize risks to research subjects.
Effectively communicate orally and in writing with colleagues and the public.
Work effectively with the diverse community.
Work effectively within a multidisciplinary research team.
Display effective leadership
Manage a research project (personnel, budget)

11. Read a literature other than your own

12. Communicate daily with people who speak a different scientific language

13. Practice systems thinking

14. Get to know the patient, family, stakeholder

15. Talk to clinicians. How does research affect clinical care?

16. Find a mentor, or a role model outside your focus
“I’m not a role model…Parents should be role models.”

17. Clinical and Translational Research Education at OHSU - HIP
Master of Clinical Research
Certificate program (2 years)
Focused education in informatics, epidemiology, biostatistics, basic sciences
Mentored capstone
Certificate in Human Investigations
Required didactic coursework (2 years)
Non-degree
Attend courses in C/T research

18. HIP Courses of Potential Interest
HIP511-3 Clinical Research Design
HIP511a Proposal Development
HIP 528,9 Applied Biostatistics
HIP 512A Biostatistics with STATA
HIP 516 Protection of Human Subjects
Responsible Conduct of Research
HIP 530 Leadership Skills for Team Science
HIP 531 Project Management
HIP 532 Understanding and Managing in Academic Organizations
Scientific Review Practicum
HIP 517 Scientific Writing and Data Presentation
HIP 527 Systematic Reviews
HIP 523 Computerized Data Management
HIP 520 Medical Informatics
HIP 507A Evidence-Based Medicine
HIP 514 Molecular and Cellular Approaches to Disease
HIP 534 Health Disparities Research
HIP 533 Community-based Research
BMI 530/630 Practice of Health Care

21. OCTRI RESEARCH INFRASTRUCTURE
Serving scientists and facilitating partnerships
Industry
new
investigators
pilot funds
OHSU
Partners
OCTRI RESEARCH INFRASTRUCTURE
research space, biostatistics, informatics, core labs, populations, scientific communities, expertise, coordination

22. Designing a Study
Statistical support with grant submissions, study design, and analysis plans
Feasibility analyses using Epic data or ResearchMatch
Budget development for grant submissions and clinical trials
Consulting with OCTRI experts on data management, laboratory analysis, community-engagement
Design Studio

23. Fulfilling Compliance Requirements
Compliance preparation and submission
− OHSU, VA IRBs
− Biosafety, Radiation, and Knight review committees
Data Safety Monitoring Plan
FWA Assurance for community partners
Drug compliance, coordination, and reconciliation

24. Implementing a Study
Comprehensive study start-up and coordination services
Clinical research facility with skilled research nurses
− Experienced study coordinators
Laboratory services
Bionutrition services for feeding studies
Body composition and energy expenditure measurements

25. Contacts OCTRI Services Human Investigations Program
OCTRI Research Navigator (Kitt Swartz)
Human Investigations Program
Karen McCracken
Cynthia Morris