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Experimental study on a new tracheal prosthesis made from collagen-conjugated mesh  Norihito Okumura, MD, Tatsuo Nakamura, MD, Tohru Natsume, MD, Kenji.

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Presentation on theme: "Experimental study on a new tracheal prosthesis made from collagen-conjugated mesh  Norihito Okumura, MD, Tatsuo Nakamura, MD, Tohru Natsume, MD, Kenji."— Presentation transcript:

1 Experimental study on a new tracheal prosthesis made from collagen-conjugated mesh 
Norihito Okumura, MD, Tatsuo Nakamura, MD, Tohru Natsume, MD, Kenji Tomihata, Yoshito Ikada, MD, PhD, Yasuhiko Shimizu, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 108, Issue 2, Pages (August 1994) DOI: /uri:pii:S Copyright © 1994 Mosby, Inc. Terms and Conditions

2 Fig. 1 Tracheal prosthesis made from collagen-conjugated mesh. For manufacturer information, see text. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /uri:pii:S ) Copyright © 1994 Mosby, Inc. Terms and Conditions

3 Fig. 2 Fabricating method of collagen-plastic composite. UV, Ultraviolet. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /uri:pii:S ) Copyright © 1994 Mosby, Inc. Terms and Conditions

4 Fig. 3 Photographs taken through fiberoptic bronchoscope. A, One month after operation; prosthesis has been already infiltrated by host connective tissue. B, Three months after operation; luminal surface of prosthesis appears partially lustrous, indicating mucosal maturation. C, Six months after operation; whole luminal surface seems smooth and lustrous. D, Twenty-four months after operation; color and luster of prosthetic lumen are similar to those of native trachea, with minimal luminal stenosis. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /uri:pii:S ) Copyright © 1994 Mosby, Inc. Terms and Conditions

5 Fig. 4 Macroscopic views of the reconstructed trachea 6 months after operation (dog No. 6). Top, External view; prosthesis (between arrows) is completely incorporated into host and retains its original shape by means of polypropylene spiral, which acts as tracheal cartilage. Bottom, Internal view; inner surface is covered with smooth and lustrous soft tissue similar to that of native trachea. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /uri:pii:S ) Copyright © 1994 Mosby, Inc. Terms and Conditions

6 Fig. 5 Photomicrograph of longitudinal section taken from prosthesis 21 months after operation (dog No.8). Continuous cover of respiratory epithelium overlying a thin layer of connective tissue containing small vessels is seen (hematoxylin and eosin stain, original magnification ×40). Arrow shows anastomotic site; TL, tracheal lumen; P, prosthesis. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /uri:pii:S ) Copyright © 1994 Mosby, Inc. Terms and Conditions

7 Fig. 6 High-power microscopic view taken from the lining of the prosthesis 6 months after operation (dog No. 6). Top, Pseudostratified columnar ciliated epithelium with basement membrane covers prosthetic lumen. Bottom, Midportion of the prosthesis is covered with layer of stratified squamous epithelium (hematoxylin and eosin stain, original magnification × 200). P, Prosthesis. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /uri:pii:S ) Copyright © 1994 Mosby, Inc. Terms and Conditions

8 Fig. 7 Scanning electron photomicrographs taken from inner surface of prosthesis 6 months after operation (dog No. 6). Left, Marginal portion close to the anastomotic site; long and uniform cilia grow thick. Right, Midportion of the prosthesis; nonuniform cilia are scattered, and microvilli are evident around them. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /uri:pii:S ) Copyright © 1994 Mosby, Inc. Terms and Conditions

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