Presentation is loading. Please wait.

Presentation is loading. Please wait.

Mismatch negativity and low frequency oscillations in schizophrenia families  L. Elliot Hong, Lauren V. Moran, Xiaoming Du, Patricio O’Donnell, Ann Summerfelt 

Similar presentations


Presentation on theme: "Mismatch negativity and low frequency oscillations in schizophrenia families  L. Elliot Hong, Lauren V. Moran, Xiaoming Du, Patricio O’Donnell, Ann Summerfelt "— Presentation transcript:

1 Mismatch negativity and low frequency oscillations in schizophrenia families 
L. Elliot Hong, Lauren V. Moran, Xiaoming Du, Patricio O’Donnell, Ann Summerfelt  Clinical Neurophysiology  Volume 123, Issue 10, Pages (October 2012) DOI: /j.clinph Copyright © 2012 International Federation of Clinical Neurophysiology Terms and Conditions

2 Fig. 1 Channels used for data analysis (A) and standard (B), deviant (C), and duration MMN (D) grand average waveforms at FZ for normal controls, schizophrenia patients and first-degree relatives. See Fig. 3 for statistics. Clinical Neurophysiology  , DOI: ( /j.clinph ) Copyright © 2012 International Federation of Clinical Neurophysiology Terms and Conditions

3 Fig. 2 Decomposition of time-scale (frequency) activities from a randomly selected single trial in response to a duration deviant stimulus in a schizophrenia patient, using 8-level bio5.5 discrete wavelet. Note that this graph is a technical illustration only: single trial data vary greatly from trial to trial. Time 0 indicates the onset of the duration deviant stimulus. Activities from 25 to 275ms were extracted for calculation of power (PSD). The y-axis is scaled differently in different detail scales in this illustration. There were no discernable evoked oscillatory signals that could be easily observed from the original single trial recording (top). With the discrete wavelet transform, it appeared that very small but discernable energy changes might have appeared at detail level D3 (85–150Hz), D6 (12–20Hz), D7 (5–12Hz), and D8 (1–5Hz), as marked by the red ovals. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) Clinical Neurophysiology  , DOI: ( /j.clinph ) Copyright © 2012 International Federation of Clinical Neurophysiology Terms and Conditions

4 Fig. 3 Duration and pitch/duration MMN amplitudes and latencies measured at FZ. ∗∗∗p<0.001; ∗p<0.05. Clinical Neurophysiology  , DOI: ( /j.clinph ) Copyright © 2012 International Federation of Clinical Neurophysiology Terms and Conditions

5 Fig. 4 A–B: Oscillatory activities in response to standard and deviant sounds (mean±SE). The data for 10 channels are arranged as 3 groups of channels from left hemisphere (F7, T7, P7), midline (FZ, CZ, PZ, OZ), and right hemisphere (F8, T8, P8), and arranged at an anterior-to-posterior orientation. Statistics are in Table 1. PSD: power spectrum density (unit: dB/Hz). L: left. Clinical Neurophysiology  , DOI: ( /j.clinph ) Copyright © 2012 International Federation of Clinical Neurophysiology Terms and Conditions

6 Fig. 5 Relationship of single trial evoked theta-alpha response and MMN. Top panel: standard sound evoked theta-alpha and MMN; middle panel: deviant sound evoked theta-alpha and MMN; bottom panel: standard minus deviant theta-alpha and MMN. The negative sign in most cases demonstrates that deviant sounds evoked higher theta-alpha than standard sounds in most subjects across groups. PSD: power spectrum density. SSP: schizophrenia spectrum personality trait. The regression statistics for the SSP group excluded the outlier with MMN over 11uV. Clinical Neurophysiology  , DOI: ( /j.clinph ) Copyright © 2012 International Federation of Clinical Neurophysiology Terms and Conditions


Download ppt "Mismatch negativity and low frequency oscillations in schizophrenia families  L. Elliot Hong, Lauren V. Moran, Xiaoming Du, Patricio O’Donnell, Ann Summerfelt "

Similar presentations


Ads by Google