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More detailed view of the process shown in Fig

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Presentation on theme: "More detailed view of the process shown in Fig"— Presentation transcript:

1 More detailed view of the process shown in Fig. 178-1
More detailed view of the process shown in Fig Both plasminogen activators, tPA and uPA, are shown. Plasmin also activated tPA and uPA to form an amplification loop. PAI-1 binds to vitronectin, which stabilizes PAI-1 in the active form and localizes PAI-1 to the subendothelial matrix. Specific cellular receptors for uPA (uPAR), tPA, and plasminogen are indicated. Plasmin binds to fibrin, where it is protected from inhibition by α2AP. Fibrin also accelerates the activation of plasminogen by tPA. TAFI is activated by thrombin and inhibits fibrinolysis by removing lysine-binding sites for tPA and plasminogen. PAI-1 may form another link between hemostasis and fibrinolysis by inhibiting thrombin. Source: Disorders of the Fibrinolytic System, The Online Metabolic and Molecular Bases of Inherited Disease Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: Accessed: October 06, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

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