1. Director, Professor Stéphan CHEVALIER
Director, Professor Stéphan CHEVALIER
Welcome to Tours, Thank you very much for taking the time to come to see us and to examine our scientific achievements and research program, we hope you will have an enjoyable day with us.
Our laboratory is ideally located in this building on the site of the hospital and research laboratories specialized in health and medical sciences.

2. “Nutrition, Croissance et Cancer”
Initiated in UMR Inserm since 2002
Clinical and fundamental project at the intersection of the two fields of
Nutrition and Cancer
NUTRITIONAL LIPIDS,
Adipose tissue, Tumors, Cell membranes
Patentable lipids with specific modes of action
Our lab was initiated at the end of the 80s and it became a inserm research unit in The research project is at the intersection of Nutrition and Cancer with an equilibrium between clinical and fundamental sciences investigations.
The lab is well known for its findings on the impact of nutritional omega 3 polyunsaturated fatty acid on breast cancer and metastases.
We have been interested in identifying nutritional lipids from…and patentable lipids such as omega 3…..to improve….
to improve the efficacy of anticancer therapy and restrain tumor progression
and to prevent metastasis occurrence and/or cancer cachexia 2

3. 15 permanent staff (11 HDR = PI) in January 2012
A multidisciplinary team
15 permanent staff (11 HDR = PI) in January 2012
CLINICAL ONCOLOGY
CLINICAL NUTRITION
Charles COUET, PU-PH
François LABARTHE, PU-PH
François MAILLOT, PU-PH
Philippe BOUGNOUX, PU-PH
Lipid chemistry and biochemistry
Michelle PINAULT, IE
Violetta GUÉRIN, AJT
Cyrille GUIMARAES Tech, (CDD ARD2020)
Cell and Tissue culture
Isabelle DOMINGO, AJT
Elsa LEMAITRE Tech (CDD ARD2020)
Stéphane SERVAIS , MCU-HDR
Stéphan CHEVALIER, PU
Karine MAHÉO, MCU-HDR
Christophe VANDIER, PU
Gunther WEBER, PU
Jacques GORE, PU
Pierre BESSON, MCU
Sébastien ROGER, MCU-HDR
We are a multidisplinary research team with competences in clinical nutrition, clinical oncology and experimental biochemistry and physiology, with a specialization in lipid biochemistry.
Back in january 2012, we were 15 permanent staff, 11 of which had a HDR, this is in France the highest university diploma permitting to be a principal investigator.
EXPERIMENTAL
BIOCHEMISTRY
PHYSIOLOGY

4. A multidisciplinary team
DU: Prof. S. Chevalier
CLINICAL ONCOLOGY
CLINICAL NUTRITION
Charles COUET, PU-PH
François LABARTHE, PU-PH
François MAILLOT, PU-PH
Régis HANKARD, PU-PH
Pierre-Henri DUCLUZEAU, PU-PH
Philippe BOUGNOUX, PU-PH Emérite
Gilles BODY, PU-PH
Driffa MOUSSATA, PU-PH
Mehdi OUAISSI, PU-PH
Secretary
Catherine LE ROY, AJT
Lipid chemistry and biochemistry
Michelle PINAULT, IE
Violetta GUÉRIN, AJT
Cyrille GUIMARAES Tech, (CDD ARD2020)
Cell and Tissue culture
Isabelle DOMINGO, AJT
Elsa LEMAITRE Tech (CDD ARD2020)
Cancéropôle Grand-Ouest
Aurore LECAILLE, IH
Stéphane SERVAIS, PU
Jean-François DUMAS, MCU-HDR
Gaëlle FROMONT, PU-PH
Lobna OULDAMER, PHU-HDR
Caroline GOUPILLE, PHA-PhD
Marie-Lise JOURDAN, PHA – PhD-HDR
Stéphan CHEVALIER, PU
Karine MAHÉO, PU
Christophe VANDIER, PU
Gunther WEBER, PU
Jacques GORE, PU Retired
Pierre BESSON, MCU
Sébastien ROGER, MCU-HDR-IUF
Marie POTIER-CARTEREAU, MCU-HDR
Aurélie CHANTÔME, IGR-PhD
We have had a tremendous support from the university and the hospital to recruit permanent staff from other faculties.
New recruits are specialized in digestive cancers, prostate cancer, gynecological cancers, clinical nutrition, experimental biochemistry and experimental physiology;
2 Lecturers were promoted to professorship and one obtained a prestigious tenure from the institut universitaire de France.
As today, we are 28 permanent staff, of which 20 PI, making a total of 15 research FTEs.
EXPERIMENTAL
BIOCHEMISTRY
PHYSIOLOGY
28 permanent members (20 HDR) - 15 permanent research FTEs3 permanent full time research scientists
+ 10 non-permanent FTEs (1 HDR): 2 will apply to inserm tenure in 2017

5. A multidisciplinary team
DU: Prof. S. Chevalier
CLINICAL ONCOLOGY
CLINICAL NUTRITION
Charles COUET, PU-PH
François LABARTHE, PU-PH
François MAILLOT, PU-PH
Régis HANKARD, PU-PH
Pierre-Henri DUCLUZEAU, PU-PH
Philippe BOUGNOUX, PU-PH Emérite
Gilles BODY, PU-PH
Driffa MOUSSATA, PU-PH
Mehdi OUAISSI, PU-PH
Secretary
Catherine LE ROY, AJT
Lipid chemistry and biochemistry
Michelle PINAULT, IE
Violetta GUÉRIN, AJT )
Cell and Tissue culture
Isabelle DOMINGO, AJT
Elsa LEMAITRE Tech (CDD ARD2020)
Cancéropôle Grand-Ouest
Aurore LECAILLE, IH
Stéphane SERVAIS, PU
Jean-François DUMAS, MCU-HDR
Gaëlle FROMONT, PU-PH
Lobna OULDAMER, PHU-HDR
Caroline GOUPILLE, PHA-PhD
Marie-Lise JOURDAN, PHA – PhD-HDR
Stéphan CHEVALIER, PU
Karine MAHÉO, PU
Christophe VANDIER, PU
Gunther WEBER, PU
Pierre BESSON, MCU
Sébastien ROGER, MCU-HDR-IUF
Marie POTIER-CARTEREAU, MCU-HDR
Aurélie CHANTÔME, IGR-PhD
Philippe FRANK, HDR (CDD ARD2020)
Jorge GUTIERREZ-PAJARES, CR Studium
Emeline BON, IGR-PhD (CDD IUF)
Ana BOUCHET, IGR-PhD (CDD Europe)
Lucie BRISSON, IGR-PhD (CDD Europe)
Romain FELIX, IGR-PhD (CDD INCa)
4 of us, with their name highlighted in green, are permanent full time research staff.
EXPERIMENTAL
BIOCHEMISTRY
PHYSIOLOGY
28 permanent research members (20 HDR) - 15 permanent FTEs
including 4 permanent full time research scientists
+ 10 non-permanent FTEs (1 HDR): 2 will apply to inserm tenure in 2017

6. A multidisciplinary team
DU: Prof. S. Chevalier
CLINICAL ONCOLOGY
CLINICAL NUTRITION
Charles COUET, PU-PH
François LABARTHE, PU-PH
François MAILLOT, PU-PH
Régis HANKARD, PU-PH
Pierre-Henri DUCLUZEAU, PU-PH
Arnaud DE LUCA, PHU
Bruno LEFORT, PHU - PhD Student
Philippe BOUGNOUX, PU-PH Emérite
Gilles BODY, PU-PH
Driffa MOUSSATA, PU-PH
Mehdi OUAISSI, PU-PH
Carina RUA, CCA
Armelle CONFAVREUX, CCA
Secretary
Catherine LE ROY, AJT
Lipid chemistry and biochemistry
Michelle PINAULT, IE
Violetta GUÉRIN, AJT
Cyrille GUIMARAES Tech, (CDD ARD)
Cell and Tissue culture
Isabelle DOMINGO, AJT
Julie COURNET Tech (CDD INCa)
Cancéropôle Grand-Ouest
Aurore LECAILLE, IH
Gaëlle FROMONT, PU-PH
Lobna OULDAMER, PHU-HDR
Caroline GOUPILLE, PHA-PhD
Marie-Lise JOURDAN, PHA – PhD-HDR
Roseline GUIBON, Tech (CDD CHU/Univ)
Stéphane SERVAIS, PU
Jean-François DUMAS, MCU-HDR
Adeline DOLLY, PhD Student
Céline BEN HASSEN, PhD Student
Sandy FIGIEL, PhD Student
Delphine FONTAINE, PhD Student
Yann FOURBON, PhD Student
Fréderic GRADEK, PhD Student
Chahrazed HABES, PhD Student
Sana KOUBA, PhD Student
Lucile POISSON, PhD Student
Stéphan CHEVALIER, PU
Karine MAHÉO, PU
Christophe VANDIER, PU
Gunther WEBER, PU
Pierre BESSON, MCU
Sébastien ROGER, MCU-HDR-IUF
Marie POTIER-CARTEREAU, MCU-HDR
Aurélie CHANTÔME, IGR-PhD
Lucie BRISSON, IGR-PhD (CDD Europe)
Philippe FRANK, HDR (CDD ARD)
Jorge GUTIERREZ-PAJARES, CR Studium
Emeline BON, IGR-PhD (CDD ARD)
Ana BOUCHET, IGR-PhD (CDD ARD)
Romain FELIX, IGR-PhD (CDD SATT)
Emiliane TAILLEBOIS, ATER
The permanent staff has been reinforced with non-permanent staff in all areas of activities for a total of 11 research FTE
as today, 2 postdocs are currently applying for research tenure at inserm and finally, there are currently 10 PhD students,
making a total of over 50 persons active on our research program
EXPERIMENTAL
BIOCHEMISTRY
PHYSIOLOGY
28 permanent research members (20 HDR) - 15 permanent FTEs
including 4 permanent full time research scientists
+ 11 non-permanent FTEs (1 HDR): 2 apply to Inserm tenure in 2017, and 10 PhD students

7. National institutional links & Boards membership
CSS3 “Physiology and physiopathology” (JF Dumas)
CSS2 “ Developmental pathology, hematology and oncology ”
(M Potier-Cartereau)
Administrative Board (S Servais)
Scientific & Academic Boards (S Chevalier)
Hospital Medical Board
(F Maillot, F Labarthe & G Fromont)
National Alimentation Cancer Research network (S Servais)
Ion channels network (C Vandier)
Prostate cancer network (G Fromont)
Interrégion Grand Ouest
Human Nutrition Research network (S Servais & R Hankard)
Several members of our lab have been elected or are sitting in our main institutional boards….JF Dumas and M Pottier have been elected in scientific boards at inserm, S Servais seat…

8. Major scientific areas of achievements from 2011 to 2016
Lipids in Nutrition & Cancer
- Identified new targets (NaV1.5-NHE1, β4 subunit, P2X7, eNOS, PPARβ, PKCε/δ) and new mechanisms by which long chain n-3 PUFA reduce mammary tumor progression and improve response to anticancer treatments.
Prevented bone metastases occurrence in pre-clinical models of mammary tumor with an ether- lipid targeting the SK3-Orai1 complex in lipid raft.
we have identified 3 major areas of scientific achievements,
we published in a number of international journals several original new targets and new mechanisms by which omega 3 fatty acids reduce mammary tumor progression and improve response to anticancer treatments.
I won’t go in the details in this short overall presentation now, this will be described in the scientific presentations since this findings are the basis of the laboratory project for the coming years.
We also managed to prevent……targeting specifically this ion channel complex. The third main scientific achievement is the demonstration…
Demonstrated in a preclinical model that cancer cachexia provoked liver mitochondrial defects (energy metabolism) regulated by TNFα due to the accumulation of cardiolipins, and that it can be reversed by the inhibition of cardiolipin synthase.

9. 6 Research contracts with private sector
Scientific production and valorization
from January 2011 to June 2016
Contract
Research FTEs
Publications
Publi > IF 5 24 84 23
2011-mid 2016 38
179 55
Other documents produced include 109 peer-reviewed medical publications (48 signed as first or last author)
18 PhD and 5 HDR viva, 107 non-PhD students trained (including 34 M2R)
Annual budget for UMR1069 projects (not including salaries of permanent FTE and Clinical research projects) funding has tripled since 2011 with regional and national grants reaching 1.2 M€ in 2016
Our scientific production has increased dramatically in comparison to the previous contact from ,
The number of research FTE has increased by a third from 24 to 38 FTE including permanent, non-permanent staff and PhD students. This growth in research potential is mostly due to recruitment of permanent staff as I already mentioned,
The number of pub of the lab has more than doubled from 84 on the previous contract to 179…..18 students were successful in obtaining their PhD, and 5 lab members obtained the HDR…The funding come from research contract obtained from…and 6…
There were 4 clinical research projects piloted by lab members and two clinical studies you will hear about during Stephane servais’ scientific presentation
6 Research contracts with private sector
CERB (Bourges), SMARTOX (Gieres), Key-Obs (Orléans), Atlantic Bone Screen (Nantes),
Nutrialys (Rennes), Mitologics SAS (Paris)

10. International collaborations and communications
Bari (Italy)
Brussels (Belgium)
Leeds (UK)
Murcia (Spain)
Baltimore (USA)
Birmingham (USA)
Philadelphia (USA)
San Marcos (USA)
Edmonton (Canada)
Manitoba (Canada)
Montréal (Canada)
Fès-Taza (Morocco)
Tunis (Tunisia)
S Reshkin (Bari, Italy) and LH Jiang (Leeds, UK) were granted visiting professor fellowships
Marie-Curie PRESTIGE fellowships were granted to L Brisson and AM Bouchet in 2015.
1rst international workshop “Lipids, nanotechnology and Cancer“ with 11 international speakers was organized in Tours in october 2016.
The 6th “European Calcium Society” workshop “Calcium and Cell fate”, with 25 international speakers was organized in Tours in april 2015.
Since 2011, organization of the Biomedical conferences of the University with 47 seminars including 18 given by international scientists.
88 posters and 52 oral communications presented by PhD students, 8 received poster prizes.
111 oral and 97 invited communications presented by UMR1069 members (other than students), 45 of which were presented in international meetings held outside of France.
Finally, we have been very active in setting up international productive collaborations in Europe, oversea in USA and Canada and in north Africa…
we pay a lot of attention that our students present their findings in conferences…
over 200 oral or invited communications were given by permanent staff, a quarter of which in international meetings held outside of France.

11. Director, Professor Stéphan CHEVALIER
Director, Professor Stéphan CHEVALIER
With this, thank you very much for your attention.