1. SEMINAR ON POLYMER SCIENCE
PRESENTED BY:
KANTILAL B. NARKHEDE
M.PHARM.1st SEMESTER
DEPT. OF P’CEUTICS,
SND COLLEGE OF PHARMACY.

2. CONTENT: Introduction Types of Polymer Classification Polymerization
Molecular weight determination
Thermal characterization
Pharmaceutical Applications
Bio degradable polymers
Application of biodegradable polymers
References.

3. INTRODUCTION Definition :
A polymer is a large molecule (macromolecule)
composed of repeating structural unit connected by covalent chemical bonds.
- The word is derived from the Greek words (poly), meaning
"many"; and (meros), meaning "part"
Example:- Butadiene, poly-vinyl-chloride etc.
- They are complex and giant molecules and are different from
low molecular weight compounds.
-`Macro-molecules’ are made up of much smaller molecules.

4. Types Of Linking In Polymers
Linear Polymers:
A polymer in which the molecules form long chains without branches or cross-linked structures.
examples: nylon, polyester, PVC etc.

5. Branched Polymer:
A polymer chain having branch points that connect three or more chain segments.
Examples: polythene, glycogen, starch etc

6. Cross linked Polymer:
Cross-links are bonds that link one polymer chain to another. They can be covalent bonds or ionic bonds.
Examples: malamine formaldehyde resin etc
Linear & Branched Polymers are know as thermoplastic materials.
Cross linked Polymer are know as thermosetting materials.

7. Classification of Polymers (According to their properties & characteristics.)
1) Natural and Synthetic Polymers.
2)Organic and Inorganic Polymers.
3)Thermoplastic and Thermosetting Polymers.
4)Plastics, Elastomers, Fibers, and Liquid Resins

8. Natural and Synthetic Polymers:
Natural Polymers Synthetic Polymer
-Cotton Polyethylene
-silk PVC
-wool Nylon
-rubber

9. 2) Organic and Inorganic Polymers:
A Polymer whose backbone chain is essentially made of carbon
atoms is termed an Organic polymer.
Examples- cellulose, proteins, polyethylene, nylons.
A Polymer which does not have carbon atom in their backbone chain is termed as Inorganic polymer.
Examples- Glass and silicone rubber

10. 3) Thermoplastic and Thermosetting Polymer:
Some polymer are soften on heating and can be converted into any
shape that they can retain on cooling.
Such polymer that soften on heating and stiffen on cooling are
termed as `thermoplastic’ polymers.
Ex. Polyethylene, PVC, nylon, sealing wax.
Polymer that become an infusible and insoluble mass on heating are called ‘thermosetting’ polymers.

11. 4)Plastic, Elastomers, Fibers and Liquid Resins:
A polymer is shaped into hard and tough utility articles by
application of heat and pressure, it is used as ‘plastic’
e.g. PVC
When vulcanized into rubbery products exhibiting good strength and elongation, polymers are used as ‘Elastomers’
e.g. Natural rubber

12. polymerization
Polymerization is a process of bonding monomer, or “single units” together through a variety of reaction mechanisms to form longer chains named Polymer
As important as polymers are, they exist with monomers, which are small, single molecules such as hydrocarbons and amino acids
These monomers bond together to form polymers. The process by which these monomers bond is called polymerization

13. Types of polymerization
Addition polymerization
Condensation polymerization

14. Addition polymerization
A carbon – carbon double bond is needed in the monomer
A monomer is the small molecule that makes up the polymer. C H n e t h i g p r s u / a c O 2 l y o ( )

15. Addition polymerisation
The polymer is the only product.
Involves the opening out of a double bond.
The conditions of the reaction can alter the properties of the polymer.
Reaction proceeds by a free radical mechanism.
Conditions are high pressure and an oxygen initiator.
Oxygen often used to provide the initial free radical.

16. Condensation Polymerisation
Involves 2 monomers that have different functional groups.
They also involve the elimination of water or another small molecule.
Hence the term condensation polymer.
Monomer A + Monomer B  Polymer + small molecule (normally water).
Common condensation polymers include polyesters (the ester linkage) and polyamides (the amide linkage as in proteins).

17. Condensation Polymeization
The example here is terylene, a polymer of benzene-1,4-dicarboxylic acid and ethane-1,2-diol.
hhhhhhhhhhhhhhhhhhh+ nH2O H O C n + 2 h e a t w i c d l y s p o ( - 1 , b z 4 r x )

18. Molecular weight determination
There are two ways to calculate the average molecular weight:
1. Number Average Molecular Weight
2. Weight Average Molecular Weight

19. Molecular weight determination
1. Number Average Molecular Weight
Molecular weight is determined by calculating the total molecular weight of monomer and total number of monomer.
Mi- total molecular weight of monomer.
Ni- number of monomer molecules.
Mn- number average molecular weight.

20. Molecular weight determination
2. Weight Average Molecular Weight
M - weight average molecular weight.
Mi- total molecular weight of monomer.
Ni- number of monomer molecules.

21. Thermal characterization
Thermal analysis of the polymers is the important phenomenon to study the stability and degradation of polymers.
Method :-
a) TGA
b) DSC
c) Thermo mechanical analysis

22. THERMOGRAVIMETRICAL ANALYSIS (TGA)
This method provides indication for thermal stability and upper limit of thermal degradation where loss of sample begins.
This method only measures loss of volatile content from the polymer.
This method has limitation that it can not detect temperature at chain cleavage of chain takes place.

23. Differential Scanning Calorimetry (DSC)
parameters measured-
Glass transition temperature (Tg)
Crystalline melting point
Heat of fusion
Heat of crystallization
It requires placing of Reference and test sample for the continuous monitoring in the heating chamber.

24. Differential Scanning Calorimetry (DSC)24 24

25. Thermo Mechanical Analysis (TMA)
This method is used for determination of deformation of polymer sample as a function of temperature placed on platform in contact with probe.
It measures transition from glassy to a rubbery polymer and gives idea about softening temperature.

27. APPLICATIONS IN PHARMACEUTICALS INDUSTRY
Mainly used for drug delivery.
As a coating material
examples: Hydroxyl propyl methyl cellulose(HPMC), Methyl cellulose,
Propylene glycol.
As a binders in tabletting granulation
examples: Acacia, Gelatin, Sodium alginate.
As a disintegrants
examples: starch,HPMC

28. APPLICATIONS
As a thickening agent in suspension and ophthalmic preparations
Example: methyl cellulose.
To form bases in ointments.
In hard and soft capsule gelatin is used.
Gelatin also used as suppository base, as an emulsifying agent and suspending agent.

29. APPLICATIONS For microencapsulation polymers are used.
Examples: Ethyl cellulose, Gelatin, Acacia, Polyvinylpyrrolidone etc.
Biodegradable polymers are used nowadays in drug delivery.
Examples: polyesters, proteins, carbohydrates.
In packaging material polymers are widely used
Examples: polyethylene, polyvinyl chloride, polyolefin etc.

30. BIO DEGRADABLE POLYMER
Material progressively releasing dissolved or dispersed drug, with ability of functioning for a temporary period and subsequently degrade in the biological fluids under a controlled mechanism, in to product easily eliminated in body metabolism pathway.

31. BIO DEGRADABLE POLYMER
Biodegradable polymers can be classified in two:
Natural biodegradable polymer
examples: xanthum gum, gaur gum, chitosan, chtin etc.
Synthetic biodegradable polymer
examples: Polyanhydrides, Poly(ß-Hydroxybutyric Acidc) etc.
Synthetic biodegradable polymer are preferred more than the natural biodegradable polymer because they are free of immunogenicity & their physicochemical properties are more predictable &reproducible

32. ADVANTAGES OF BIODEGRADABLE POLYMERS IN DRUG DELEVERY
Localized delivery of drug
Sustained delivery of drug
Stabilization of drug
Decrease in dosing frequency
Reduce side effects
Improved patient compliance
Controllable degradation rate

33. APPLICATIONS Wound management Orthopedic devices Tissue engineering
Sutures
Orthopedic devices
Rods
Screws Staples
Ligaments
Pins
Tissue engineering
Dental applications
Guided tissue regeneration Membrane
Void filler following tooth extraction

34. REFERENCES
Govariker V. R., Viswanathan N. V., Sreedhar J., “Polymer Science”, New age publications,
Jain N.K., Controlled and novel drug delivery, CBS Publisher,New delhi,
Martin A., Swarbrick J., Commarata A., Physical pharmacy, K.M.varghese company, Bombay,
Biodegradable Polymer as drug delivery system; “Synthetic polysaccharides”; edited by-Mark Chasin, Robert Langer Vol ; Page No-43-49,71-90,

35. REFERENCES
Sinko P.J.,Physical pharmacy and pharmaceutical sciences, fifth edition, lippincot williams & wikins co.,

36. THANK YOU