1. Dr. Brian Lipscomb Office: HLSC 346
Office Hours: T 10:00-12:00; Fri. 2:30-4:30
Lecture Times: MWF 10:00-10:50 Gregory 114
MWF 11:00-11:50 Gregory 114

2. Required Texts
Human Anatomy & Physiology (9th or 10th Edition) Elaine N. Marieb , Katja Hoehn
Benjamin Cummings

3. Online Resources: Power Point files used in lecture will be posted on the web. POSTED LECTURE FILES ARE NOT A SUBSTITUE FOR ATTENDING LECTURE OR READING YOUR TEXTBOOK.
Handouts and diagrams to be used for class will be posted.
Material to be reviewed and printed for lab will also be posted online.

4. A and P II Intro
Contact Information
Using Slides
Grades
Class Expectations
What is this Course about?
Handouts: Basic Cell
Marieb-none

5. Grading Policy
There are a total of 520 points associated with the course:
Test 1: 80 pts
Test 2: 70 pts
Test 3: 65 pts
Test 4: 80 pts (given with final)
Final: 50 pts (Cumulative- focuses on material from Tests 1-3)
Homework: 20 pts (4 X 5 pts)
Lab: 155 pts 

6. Grading Scale:
A pts
B pts
C pts
D pts

7. Attendance and Classroom Behavior
Disruptive behavior in class will not be tolerated. Texting, web browsing, searching for Pokemon, excessive talking, etc. is annoying to your fellow students. You may use computers in class, but limit your activities to taking notes or this privilege may be revoked. .

8. Laboratories
Labs will be held at the Health and Life Sciences Building, 305. Labs begin the week of August 22nd!

9. Class Expectations Study Attend Lecture Ask Questions
Don’t Get too Far Behind in Class
Be Respectful in Class and Lab

10. Blood Blood Intro Blood Plasma Cells of the Blood Stem Cells Marieb 17
Be able to define hematocrit and describe the contents of the layers that are revealed when spinning down blood.
Be able to identify some of the principle functions of blood.
Be able to describe the cellular and molecular characteristics of RBCs that allow them to carry O2 throughout the body.
Be able to identify the formed elements and where they are formed. Be able to describe the concepts of potency, lineage, and commitment specifically in relation to RBCs.
Marieb 17

11. Spinning Down Blood Blood Plasma Buffy Coat: Leukocytes Platelets
Erythrocytes
Hematocrit
Buffy coat varies as white cell numbers go up and down
Hematocrit is a simple measure of the bodies ability to carry O2
Blood is a connective tissue: cells(formed elements) and matrix (plasma)

12. Functions of Blood Distribution of molecules
Regulation of heat, pH, blood pressure
Protection
Endocrine glands pump hormones into blood
We will discuss O2 and CO2 movement in detail in respiratory lectures
Blood pH is highly controlled
Clotting is NOT part of the immune response

13. Blood Plasma Straw colored 90% H2O 8% Plasma Proteins
Dissolved gases, ions, hormones, nutrients and waste

14. Plasma Proteins Albumins α,β Globulins Fibrinogen γ Globulins
Albumins, A,B made in liver
Albumins, A, B transport molecule for lipids, fat soluble vitamins and some metal ions
Fibrinogen- clotting
gamma- antibodies

15. Formed Elements Erythrocytes Red Blood Cells (RBCs) Leukocytes
White Blood Cells
Platelets
Form in red bone marrow

16. Erythrocytes: Red Blood Cells (RBCs)
Anucleate
~ 5 million/μl
Hemoglobin
Spectrin
High SA/Volume Ratio
5 billion/ml
Spectrin is a cytoskeletal protein. In RBCs it acts as a elastic molecule
RBCs can taco
Note: birds and reptile RBCs have nuclei

17. Hemoglobin 14-20g/100mls 4 Subunits (globins) Heme group: Fe
We will cover hemoglobin more during the respiration unit

18. Hemoglobin Function Deoxyhemoglobin Oxyhemoglobin Carbaminoglobin
CO binds to hemoglobin about 200x more efficiently than O2

19. RBC Formation Hematopoiesis-blood cell formation Red marrow
Sinusoidal Capillaries
bil/day

20. Blood Cell Lineage Hemocytoblast Potency Committed cells
Lineage- family tree
Potency- measure of how many different types of cells and arise form a particular cell
Totipotent- can make all cells, even extra embryonic tissue
Pleuripotent- can make all cells of the body
Multipotent- can make all or most of the cells in a tissue type
Unipotent- can make only a single type of cell
Committed cells- point at which a particular cell is committed to its fate (usually used to discuss when a cell is multipotent)
Cell fate- process of a cell committing to a particular pathway