1. Assistant Vice Chancellor for Clinical and Translational Science
 CCTSI CU-CSU Summit #5 Microbiome Research – from Methodology to Collaboration
Ronald J. Sokol, MD
Director and PI, CCTSI
Assistant Vice Chancellor for Clinical and Translational Science

2. Welcome 5th Annual CU/CSU CCTSI Summit Goals:
Provide information about CCTSI and Microbiome Resources and Programs at each campus
Highlight ongoing Microbiome research
Promote new collaborations, scientific exchange, mentor-mentee relationships
Four Oral Sessions, Poster Session (lunch), 3x5 abstracts, Concurrent Breakout Sessions – getting started in microbiome research (3 topics, 20 minutes each), Coffee breaks, Evaluation

3. CTSA Program
A national consortium of medical research institutions collaborating to transform how clinical and translational science is conducted nationwide
Currently, 58 funded Hubs, many of which include multiple universities and hospitals.
CTSAs provide many local resources, facilities, research personnel, pilot funding, regulatory and informatics support, research units and education & training programs
Grants originate from NCATS at NIH

4. Vision of CCTSI
Accelerate and catalyze the translation of innovative science into improved health and patient care

5. History of UC Denver CTSA
CCTSI initiated on June 1, 2008
Funded by NIH Clinical and Translational Science Award (CTSA) Grant awarded in with substantial local Institutional support
5 year grant renewed in 2013 ($52 million)
One of 62 CTSA Hubs in the nation

6. UC Health
CTSA Consort

7. CCTSI Monthly Membership Growth
4,477

8. CCTSI 2013-18 Education & Training Translational Pilot Program
Academic Home
Education & Training
Translational Pilot Program
Enhanced Research Environ-ment
CTR Resources & Services
Translational Informatics

9. CCTSI Key Functions Education, Training and Career Development
Clinical Research Resources & Facilities (CTRCs)
Community Engagement & Research
Child & Maternal Health Research
Biostatistics, Epidemiology and Research Design
Translational Informatics
Research Bioethics
Regulatory Knowledge and Support
Pilot Grants and New Methods grants
Translational Technologies
Dissemination and Implementation Research
Evaluation & Tracking

10. CCTSI Website cctsi.ucdenver.edu or Google CCTSI Portal of entry
Information, applications, links to services, RFAs, training, announcements, etc.
Membership online
Need Help? Ask a Navigator
Colorado Profiles
Cite the Grant
WEBSITE:
4 - 6,000 visits per month
20, ,000 page-views
COLORADO PROFILES:
>8,000 visits per month
>20,000 page-views 10

14. Clinical Translational Research Centers
UCH, CHCO, NJH, CU-B and Perinatal
Inpatient and outpatient facilities
Research Nursing – inpatient, outpatient, mobile teams (NICU, PICU, ED, etc.)
Bionutrition and body composition
Vascular Ultrasonography
Core Laboratories & specimen processing
SARC review of protocols
All CTRCs:
420 Projects per year
New Projects per year
15,000 OP Visits per year
1,000 IP Admits per year

15. Pilot Grant Awards
6 Pilot Grant programs – CO-Pilot, CMH, Community Engagement, Ctr for NeuroScience, New Methods, CU-CSU Collab.
$1.2 million available
$20,000, 30,000, $60,000 levels
Letter of Intent in August
Deadline September (end)
Peer Review in November
Start-up in January-April

16. Education, Training and Career Development (ETCD)
Summer Undergraduate Minority Mentoring in Translational Science (SUMMiT)
TL1 (T32) Pre-doctoral PhD training program
Clinical Sciences Graduate Program (PhD, Masters)
KL2 (K12) Research Scholar program
K-Club and Nuts and Bolts
Clinical Faculty Scholars Program

17. Education, Training and Career Development (ETCD)
7. Clinical Trials Training for Investigators and Coordinators
8. Leadership in Innovative Team Science (LITeS)
9. K to R Transition Grant Review
10. Colorado Mentor Training Program
11. Pre-K Grant Review

18. Pre-K Grant Review Program
Help junior faculty and their mentors write successful career development awards
5 criteria (candidate, career development, mentors, environment, and research plan)
Mock grant reviews: 3 times a year
Applicants and mentors attend
K24 awardees, K12 directors, biostats, other K awardees are reviewers
Format: reviewers and then panel discusses, followed by Q&A
Lecture series relevant to K applicants
Spin off of our KtR program
6 first time, 12 this time

19. K to R Transition Program
Pre-grant submission mock grant review process
Faculty with K-level awards who are submitting first R-level grant award
Submit grant proposal for internal review about 4-6 weeks before submission to funding agency
Deadline for Letter of Intent
Mock study section and written reviews
PI and mentor - attend mock study section
3 cycles – NIH grant application deadlines
Maggie Wierman, MD

20. Pragmatic Trials and Dissemination/ Implementation Research Unit
To foster a learning community
Offer local high-quality educational training workshops, conferences and learning seminars.
Leverage and partner with existing local expertise and resources to support educational content creation and course delivery.
Disseminate locally (and nationally) training resources via on-line platforms.
To catalyze and centrally support researchers
Help researchers navigate available resources.
Leverage, and partner with, other CCTSI resources to address gaps.

21. I-Corps@CCTSI Program
New Train-the-Trainer pilot program started in (NCATS)
Training of teams in market assessment of feasibility for a new product
Beginnings of a new Innovation and Entrepreneurship Core in CCTSI
Elaine Morrato, DrPH, MPH

23. 2017 Grant Renewal Renewal submitted: May 25, 2017
Major changes in RFA:
Budget (Direct Costs) = 2.5% NIH funding (2016; $230M)
Rent for space – not allowed; research nurses, tests and procedures (CTRCs) – limited amount on U54 budget
No Translational Technologies supported
Allocate Support to RIC and TIC liaisons (TIN)
BERD limited to grant and project writing/planning
Pilots – no basic discovery, emphasize science of translation
More focus on Methods Development
Optional functions (n = 2)
Grant to be reviewed on Sept. 26, 2017

24. CCTSI is here to support you!
Become a Member (quick, free, powerful)
Become familiar with the website
Cite our Grant Number

25. Questions?