1. THE STTTOPPP The bleeding randoMiZed controlled trial
Martin L Tonglet, MD, PhD student, Liege University Hospital, Belgium
11th EUPHOREA meeting, Glasgow, April 25th 2017
THE STTTOPPP The bleeding randoMiZed controlled trial

2. The STOP the bleeding campaign.
“The campaign aims to reduce the number of patients who die within 24 hours after arrival in the hospital due to exsanguination by a minimum of 20% within the next 5 years.”
Rosaint et al. Crit Care. 2013 Apr 26;17(2):136.

4. Blood product use in trauma resuscitation: plasma deficit versus plasma ratio as predictors of mortality in trauma (CME).
de Biasi AR1, Stansbury LG, Dutton RP, Stein DM, Scalea TM, Hess JR.
Transfusion. 2011 Sep;51(9):

8. Prehospital Air Medical Plasma (PAMPer) Trial

10. Remote Damage Control Resuscitation - RDCR

11. Impact of plasma transfusion in trauma patients who do not require massive transfusion.
Inaba K1, Branco BC, Rhee P, Blackbourne LH, Holcomb JB, Teixeira PG, Shulman I, Nelson J, Demetriades D.
J Am Coll Surg. 2010 Jun;210(6):957-65

13. A medical need

14. What can we do so far ?

16. Two questions
1- How could we reduce delta t ? 2- How could we take advantage from delta t ?

17. The Trauma Induced Coagulopathy Clinical Score

18. The Trauma Induced Coagulopathy Clinical Score

20. Prehospital identification of trauma patients in need for transfusion: results of a retrospective study on 33,385 patients from the TraumaRegister DGU® evaluating the Trauma Induced Coagulopathy Clinical Score (TICCS). Tonglet et al. in press

21. Impact ? The STTTOPPP the bleeding RCT
Question: What is the impact of a prehospital discrimination (using TICCS) of trauma requiring or not EAHR ?
Primary outcome: difference in 7 days mortality.
Secondary outcomes: 30 days mortality, total number of blood products transfused, total hospital length of stay.

22. The STTTOPPP the bleeding RCT
Randomization
CONTROL GROUP
INTERVENTION GROUP
TICCS CALCULATION
LOCAL USUAL PROTOCOL OF CARE
TICCS < 10
TICCS ≥ 10
None of the STTTOPPP components (except trauma team)
STTTOPPP the bleeding protocol
7 days mortality, 30 days mortality, total blood products transfused, total hospital length of stay

23. The STTTOPPP the bleeding RCT

24. The STTTOPPP the bleeding RCT

25. The STTTOPPP the bleeding RCT

26. www.researchgate.net Martin L Tonglet
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Martin L Tonglet
Dr Martin Tonglet
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