1. Med Chem Tutoring January 25
By Alaina Darby

2. Know the objectives… I’m sure you have realized this by now.
Some TB drugs are prodrugs that required activation by bacterial enzymes. List up.
What is a general stain method for Mtb? Is Mtb Gram-negative or Gram-positive?
Mtb survive in host for many years by entering dormancy. Study about non-replicating Mtb.
List up the second-line TB drugs. Which one is aminoglycoside?
Molecular target of bedaquline
Molecular target of ethambutol
Structure of delemanide and its mode of action
Molecular target of rifampicin \
Study Crohn’s disease. Are antibiotic effective? What are NOD1 and NOD2?
Structure of chloroquine
Structure of artesunate. Is it orally bioavailable?
Combination chemotherapy for Plasmodium falciparum infections.
Mode of action and utility of metronidazole
Study about interferons
What are causative organisms of sexually transmitted infections (STIs)?
Study about HIV/AIDS
Nucleoside-based antiviral drugs
Antiretroviral drugs used for the treatment of HIV/AIDS .
General structures of nucleoside reverse-transcriptase inhibitors and SAR
Non-nucleoside reverse transcriptase inhibitor for the treatment of HIV
Tamiflu and its mode of action

3. Study about interferons
Which of the following types of interferon has been approved from prophylactic treatment of CMV?
Interferon-α
Interferon-β
Interferon-γ
Interferon-δ A

4. What are causative organisms of sexually transmitted infections (STIs)?
Which of the following viral infections can cause an STI?
Hepatitis A
Hepatitis B
Hepatitis C
Hepatitis D B

5. What are causative organisms of sexually transmitted infections (STIs)?
Which of the following bacteria causes syphilis?
Haemophilus ducreyi
Neisseria gonorrhea
Lymphogranuloma vereum
Treponema pallidum D

6. What are causative organisms of sexually transmitted infections (STIs)?
Which of the following is a protozoal infection that also causes a STI?
Chlamydia trachomatis
Trichomonas vaginalis
Candida albicans
Human immunodeficiency virus B

7. Study about HIV/AIDS Which of the following is not true of HAART?
May have severe side effects
Compliance is important to prevent resistance
May be of benefit to patients with low viral loads
There are no risks for patients with low viral loads D

8. Study about HIV/AIDS Which of the following is true of HIV/AIDS?
HIV-1 is more infective than HIV-2
HIV-2 is more infective than HIV-1
HIV-1 and HIV-2 are equally infective
Neither HIV-1 and HIV-2 are very infective A

9. Nucleoside-based antiviral drugs
Which of the following is not true of NRTI resistance?
Mutations in the N-terminal polymerase domain reduce enzyme affinity to bind the drug
Mutations may occur as insertions or deletions in the background
Excision enhancement mutations are selected for by thymidine analogs
Resistance to one NRTI does not confer resistance to the other NRTIs D
Slide 85

10. Antiretroviral drugs used for the treatment of HIV/AIDS .
Which of the following is not included in Atripla?
Efavirenz
Emtricitabine
Zidovudine
Tenofovir C

11. Antiretroviral drugs used for the treatment of HIV/AIDS .
Which of the following is not a component of Trizivir?
Abacavir
Emtricitabine
Zidovudine
Lamivudine B

12. General structures of nucleoside reverse-transcriptase inhibitors and SAR
Which of the following is not a nucleoside reverse-transcriptase inhibitor?
A. B.
C. D.
B… Nevirapine (non-nucleoside)

13. General structures of nucleoside reverse-transcriptase inhibitors and SAR
Which of the following describes the blue highlighted portion of the NRTIs?
May not be modified
Improves PK
Increases hydrophobicity
May be slightly modified D

14. General structures of nucleoside reverse-transcriptase inhibitors and SAR
Which of the following describes the arrow portion of the NRTIs?
May not be modified
Improves PK
Increases hydrophobicity
May be slightly modified A

15. General structures of nucleoside reverse-transcriptase inhibitors and SAR
Which of the following describes the arrow portion of the NRTIs?
Acetylation site
Phosphorylation site
Hydroxylation site
Amination site B

16. General structures of nucleoside reverse-transcriptase inhibitors and SAR
Which of the following sites increases hydrophobicity of the NRTI?
Arrow
Green
Blue
Orange B

17. Non-nucleoside reverse transcriptase inhibitor for the treatment of HIV
Which of the following is not true of NNRTIs (vs NRTIs)?
Lack nucleoside structure
Highly selective for HIV-1 strains
Require cellular activation
Interact with a non substrate binding site C

18. Non-nucleoside reverse transcriptase inhibitor for the treatment of HIV
Which of the following is true of resistance of NNRTIs?
There is cross resistance between NNRTIs and NRTIs
NNRTIs require multiple mutations for HIV to gain resistance
NNRTIs resistance is acquired faster than to NRTIs
More mutations are required to gain resistance to NNRTIs than for NRTIs C

19. Tamiflu and its mode of action
Which of the following does not describe Tamiflu?
It is the neuraminidase inhibitor
It mimics the oxonium intermediate
It impedes an enzyme found inside viruses
It is active against the influenza virus C

20. Tamiflu and its mode of action
Which of the following depicts Tamiflu?
A. B.
C. D.
B and C
A is the step that it blocks!