1. Noah Gray – Chemistry 11, Block A
Ibuprofen
Noah Gray – Chemistry 11, Block A

2. Structural diagram of ibuprofen
If you’d like to see a 3D model that you can rotate go to

3. Ibuprofens history
Ibuprofen was first developed in the early 1960’s Boots Laboratories(British drug manufacturer). Boots realized that Carboxylic Acid was what gave aspirin its anti- inflammatory qualities. The Boots laboratories found a Carboxylic acid with twice the strength as aspirin, and so they tested and made more than 600 compounds with it. Most were ineffective, but the one found most effective was Ibuprofen.
It wasn’t until 1974 when Ibuprofen arrived in the United States. It was then that a large company called Whitehall Laboratories Division came out with their Ibuprofen, and they called it Advil. It was in 1983 where it became legal to buy Ibuprofen without a subscription.

4. How is Ibuprofen synthesized?
There is two common ways to make ibuprofen:
The Boot process and the Hoechst process (They are
both shown in the image to the right). They both use
isobutyl benzene and Friedel-Crafts acylation. The
Boot process was the original way to make Ibuprofen
but the Hoechst process is a newer process that
requires fewer steps.

5. Properties of Ibuprofen
The following are properties of Ibuprofen:
Molecular Formula: C₁₃H₁₈O₂
Its appearance is generally white, in the form of powder or tablets.
Its predicted melting point is 76 degrees Celsius
According to Chemspider.com, Ibuprofen is “stable, combustible, and incompatible with strong oxidizing agents.”
Its Average mass is Da (Daltons)

6. Ibuprofens Uses in Society
Ibuprofens main uses are to reduce pain, fever, and inflammation, while as it is most commonly used for menstrual periods, migraines, and arthritis.
Ibuprofen is most commonly sold as Advil, but is also widely known by these brands: Brufen, Nurofen, Motrin, and many more.
Ibuprofen is often confused with acetaminophen. While they both help relieve pain and fever, acetaminophen does not reduce inflammation. On the other hand, Ibuprofen is tough on the stomach and has fewer side effects.
Ibuprofen can be used without a subscription, although the dose is toned down considerably compared to prescription Ibuprofen.
There are many different derivatives of Ibuprofen, and the reason for creating derivitives of Ibuprofen is to reduce the amount of gastro toxicity as a side effect.

7. Problems with Ibuprofen
There are multiple side effects from taking Ibuprofen including, but not limited to, nausea, constipation, diarrhea, gastrointestinal bleeding, headache, rash, and hypertension.
Taking alcohol with Ibuprofen has been found to increase the risk of stomach bleeding.
It is also found that taking high daily doses Ibuprofen may result in cardiovascular risk such as a heart attack or hypertension.
Overdosing on Ibuprofen usually does not result in death but a large portion of the symptoms and side effects listed above may occur.

8. Bibliography