1. NIH HIV/AIDS Research Priorities
Stacy Carrington-Lawrence Ph.D.
Office of AIDS Research National Institutes of Health

2. National Institutes of Health
Office of the Director
Office of AIDS
Research
National Institute
of Child Health
and Human
Development
National Institute
on Aging
National Institute
on Alcohol Abuse
and Alcoholism
National Institute
of Allergy and
Infectious Diseases
National Institute
of Arthritis and
Musculoskeletal
and Skin Diseases
National Cancer
Institute
National Institute on
Deafness and Other
Communication
Disorders
National Institute
of Dental and
Craniofacial
Research
National Institute
of Diabetes and
Digestive and
Kidney Diseases
National Institute
on Drug Abuse
National Institute
of Environmental
Health Sciences
National Eye
Institute
National Institute
of General
Medical Sciences
National Heart,
Lung, and Blood
Institute
National Human
Genome Research
Institute
National Institute
of Mental Health
National Institute
of Neurological
Disorders and
Stroke
National Institute
of Nursing Research
The OAR is responsible for coordinating the scientific, budgetary, legislative, and policy elements of NIH HIV/AIDS Research.
National Institute of
Biomedical Imaging
and Bioengineering
National Center
for Complementary
and Integrative Health
John E. Fogarty
International
Center
National Center
for Research
Resources
National Library
of Medicine
National Center on
Minority Health and
Health Disparities
Warren Grant
Magnuson
Clinical Center
Center for
Information
Technology
Center for
Scientific Review
DHHS/NIH/OD/OAR

3. NIH HIV/AIDS Research Portfolio
Largest public investment in AIDS research in the world ($3.0 Billion in FY 2016)
Encompasses nearly all 27 NIH ICs
Transcends every area of clinical medicine and basic scientific investigation
Multi-IC, multidisciplinary, global
Comprehensive program of basic, clinical, and behavioral research and training on HIV infection, associated co-infections (TB, malaria), comorbidities, and other complications
AIDS Research budget has remained essentially flat since 2012 and therefore NIH leadership mandated that the OAR in consultation with the OAR advisory council examine the NIH portfolio and determine areas of highest priority in order to ensure these areas received adequate support in the face of declining AIDS funding.

4. NIH Overarching AIDS Research Priorities
Critical to ensure that NIH AIDS funds are supporting the highest priorities for next 3-5 years:
Reduced incidence, including vaccines, microbicides, PrEP, TasP
Next generation of HIV therapies with better safety and ease of use
Research toward a cure
HIV-associated comorbidities and co- infections
Cross cutting areas: Basic research, behavioral and social sciences research, health disparities, and training
Although each NIH Institute or Center may have Institute specific HIV/AIDS Priorities based on their respective missions, these are overarching NIH priorities that need to be met for all projects that are supported with AIDS specific funds.

5. High Priority Research Areas For Use of AIDS Funds
Reducing incidence of HIV/AIDS including:
Developing/testing promising vaccines candidates, microbicide and PrEP candidates
Developing and testing innovative delivery methods to mitigate adherence issues
Developing, testing, and implementing strategies to improve HIV testing, entry into prevention services, and entry into treatment

6. High Priority Research Areas For Use of AIDS Funds (continued)
Next generation of HIV therapies
Treatment regimens that are less toxic with fewer side effects and complications
Longer acting
Easier to take and adhere to than current regimens
Implementation research to ensure
Initiation of treatment as soon as diagnosis has been made
Retention and engagement in services
Achievement and maintenance of optimal prevention and treatment responses

7. High Priority Research Areas For Use of AIDS Funds (continued)
Research toward a cure including: 
Developing novel approaches and strategies to identify and eliminate viral reservoirs
Basic and clinical research approaches
Lifelong remission of HIV infection
Studies of viral persistence, latency, reactivation, and eradication
HIV-associated comorbidities, coinfections, and complications including
Impact of HIV-associated comorbidities, including TB, malignancies; cardiovascular, neurological, and metabolic complications
Premature aging associated with long-term HIV disease and antiretroviral therapy

8. High Priority Cross-Cutting Areas
Basic research including studies on HIV transmission, pathogenesis, and immune dysfunction
Behavioral and social science research
Research to reduce health disparities in incidence and treatment outcomes
Training to conduct high priority research

9. Medium-Priority Research Areas
HIV/AIDS is a meaningful component of the project and/or knowledge about HIV is enhanced by the project
Project addresses health and social issues clearly linked with HIV
Morbidity and mortality
Stigma
Examines issues in the context of HIV
Other infectious pathogens and diseases
Non-infectious pathogens and diseases
Substance use/addiction
Mental health disorders
Research focus or primary outcome is not directly HIV, but may inform HIV studies or impact HIV infected individuals

10. Medium Priority Research Areas (continued)
Results will advance HIV treatment or prevention
Results provide tools/techniques and/or capacity beneficial to HIV research
Includes training and infrastructure development

11. Innovation
New or original ideas including methods, technologies, models, or more effective tools and products. The NIH RePorter is a good resource to find information on what the NIH is currently funding as well as what we have funded in the past.

12. Realistic Aims

13. Grantsmanship
Proposal should be clear and concise. Check for grammar and spelling and eliminate jargon. Don’t assume the reviewers will know abbreviations and acronyms (spell out or define).

14. NIH Session at IAS Grantsmanship Strategies and Peer Review Workshop Wednesday, July 26 Room 241 from 16:30-18:00
NIH is hosting a ‘Grantsmanship strategies and peer review workshop’ on Wednesday, July 26 at 4:30 PM. This workshop will provide advice on how to develop a competitive NIH grant application. Several experienced program and review staff from the Office of AIDS Research (OAR), the National Institute of Allergy and Infectious Diseases (NIAID), the Center for Scientific Review (CSR), and the National Institute of Mental Health (NIMH) will be available at this venue to answer your questions.

15. NIH…
Turning Discovery Into Health